Evidence shows that a substantial proportion of patients with COVID-19 experiences long-
term consequences of the disease, but the predisposing factors are poorly understood. We …

Background Identification of reliable outcome predictors in coronavirus disease 2019
(COVID‐19) is of paramount importance for improving patient's management. Methods A …

Prognostic factors are associated with the risk of future health outcomes in individuals with a
particular health condition or some clinical start point (eg, a particular diagnosis). Research …

Objective To investigate the impact of patient and public involvement (PPI) on rates of
enrolment and retention in clinical trials and explore how this varies with the context and …

Importance Early-onset colorectal cancer (EOCRC), defined as a diagnosis at younger than
age 50 years, is increasing, and so-called red flag signs and symptoms among these …

Background Recruitment for clinical trials continues to be a challenge, as patient recruitment
is the single biggest cause of trial delays. Around 80% of trials fail to meet the initial …

It is widely recommended that any developed—diagnostic or prognostic—prediction model
is externally validated in terms of its predictive performance measured by calibration and …

Background Task sharing for the management of hypertension could be useful for
understaffed and resource-poor health systems. We assessed the effectiveness of task …

Meta‐analyses are an important tool within systematic reviews to estimate the overall effect
size and its confidence interval for an outcome of interest. If heterogeneity between the …

Objective To assess the efficacy and safety of vaginal progesterone to prevent recurrent
preterm birth and adverse perinatal outcomes in singleton gestations with a history of …