The histopathological hallmark of Parkinson's disease (PD) is the presence of fibrillar
aggregates referred to as Lewy bodies (LBs), in which α-synuclein is a major constituent …

The histological hallmark of Parkinson's disease (PD) is the presence of fibrillar aggregates
called Lewy bodies (LBs). LB formation has been considered to be a marker for neuronal …

Rapidly progressive Alzheimer's disease (rpAD) is a particularly aggressive form of
Alzheimer's disease, with a median survival time of 7–10 months after diagnosis. Why these …

Multiple system atrophy (MSA) is an orphan, fatal, adult-onset neurodegenerative disorder of
uncertain etiology that is clinically characterized by various combinations of parkinsonism …

Pathology consisting of intracellular aggregates of alpha-Synuclein (α-Syn) spread through
the nervous system in a variety of neurodegenerative disorders including Parkinson's …

Z. Ahmed, YT Asi, A. Sailer, AJ Lees, H. Houlden, T. Revesz and JL Holton (2012)
Neuropathology and Applied Neurobiology38, 4–24 The neuropathology, pathophysiology …

The existence and functioning of intrinsically disordered proteins (IDPs) challenge the
classical structure-function paradigm that equates function with a well-defined 3D structure …

The present study demonstrates that blood samples can be used as a source of miRNA
identification associated to Parkinson's disease (PD). A set of six differentially expressed …

Multiple system atrophy (MSA) is a fatal adult‐onset neurodegenerative disorder of
uncertain etiology, clinically manifesting with autonomic failure associated with …

Detailed observations of transcriptional, translational and post-translational events in the
human brain are essential to improving our understanding of its development, function and …