Throughout its 40-year history, the field of gene therapy has been marked by many
transitions. It has seen great strides in combating human disease, has given hope to patients …

More than two decades have passed since genetically modified HIV was used for gene
delivery. Through continuous improvements these early marker gene-carrying HIVs have …

The human blood-brain barrier (hBBB) is a highly specialized structure that regulates
passage across blood and central nervous system (CNS) compartments. Despite its critical …

T cell-based adoptive immunotherapy has been shown to be a promising treatment for
various types of cancer. However, adoptive T cell therapy currently requires the custom …

MicroRNAs (miRNAs) are a recently identified class of epigenetic elements consisting of
small noncoding RNAs that bind to the 3′ untranslated region of mRNAs and down …

Transcription through immunoglobulin switch (S) regions is essential for class switch
recombination (CSR), but no molecular function of the transcripts has been described …

Replication defective vectors derived from simple retroviruses or the more complex
genomes of lentiviruses continue to offer the advantages of long-term expression, cell and …

Immune‐mediated inflammatory diseases (IMIDs) impose an immeasurable burden on
individuals and society. While the conventional use of immunosuppressants and disease …

We elucidate the cellular and molecular kinetics of the stepwise differentiation of human
embryonic stem cells (hESCs) to primitive and definitive erythromyelopoiesis from human …

Several members of the Kruppel-like factor (KLF) family of transcription factors play
important roles in differentiation, survival, and trafficking of blood and immune cell types. We …