Cytochrome P450 (CYP450) is a group of enzymes that play an essential role in Phase I
metabolism, with 57 functional genes classified into 18 families in the human genome, of …

ABSTRACT Introduction Various pharmacogenomic (PGx) variants differ widely in different
ethnicities. and clinical outcomes associated with these variants may also be substantially …

Many drugs are being administered to tackle coronavirus disease 2019 (COVID-19)
pandemic situations without establishing clinical effectiveness or tailoring safety. A …

Pantoprazole is used to treat gastroesophageal reflux disease (GERD), maintain healing of
erosive esophagitis (EE), and control symptoms related to Zollinger–Ellison syndrome …

The aggregated risk of major adverse cardiovascular events (MACE) in acute coronary
syndrome (ACS) patients inheriting CYP2C19 loss-of function (LoF) alleles who underwent …

Omeprazole (brand name Prilosec) is a first-generation proton pump inhibitor (PPI) used to
treat gastroesophageal reflux disease (GERD), gastric ulcers, duodenal ulcers, upper …

Background Concomitant use of clopidogrel and proton pump inhibitor (PPI) is common, but
PPI may reduce the antiplatelet effects of clopidogrel in patients undergoing percutaneous …

Background Efficacy of clopidogrel may be diminished due to either co-administration of
proton pump inhibitors or carrying CYP2C19 loss-of-function alleles. However, patients may …

Introduction Azole antifungal drugs are commonly prescribed to treat invasive fungal
infections in various disease conditions. However, these drugs are substrates and inhibitors …

Clozapine is one of the most effective antipsychotics available in the treatment of
schizophrenia and the only antipsychotic found to be effective in treatment-resistant …