Tau is well established as a microtubule-associated protein in neurons. However, under
pathological conditions, aberrant assembly of tau into insoluble aggregates is accompanied …

During an action potential, Ca 2+ entering a presynaptic terminal triggers synaptic vesicle
exocytosis and neurotransmitter release in less than a millisecond. How does Ca 2+ …

Human genetics has indicated a causal role for the protein α-synuclein in the pathogenesis
of familial Parkinson's disease (PD), and the aggregation of synuclein in essentially all …

Next-generation sequencing has identified mutations in the PRRT2 (proline-rich
transmembrane protein 2) gene as the leading cause for a wide and yet evolving spectrum …

Synaptic vesicle recycling is one of the best‐studied cellular pathways. Many of the proteins
involved are known, and their interactions are becoming increasingly clear. However, as for …

Neurotransmitter release is governed by proteins that have homo-logs in most types of
intracellular membrane fusion, including the Sec1/Munc18 protein Munc18-1 and the …

Abstract Alpha-synuclein (α-syn) has been suggested to have many functions including,
vesicle transport in neurons, transcriptional regulator, modulator of immune cell maturation …

It is now known that proteins associated with neurodegenerative disease can spread
throughout the brain in a prionlike manner. However, the mechanisms regulating the trans …

Abstract α-Synuclein is an abundant protein at the neuronal synapse that has been
implicated in Parkinson's disease for over 25 years and characterizes the hallmark …

A hallmark of synaptic specializations is their dependence on highly organized complexes of
proteins that interact with each other. The loss or modification of key synaptic proteins …