Dementia prevention, intervention, and care: 2024 report of the Lancet standing Commission
Executive summary The 2024 update of the Lancet Commission on dementia provides new
hopeful evidence about dementia prevention, intervention, and care. As people live longer …
hopeful evidence about dementia prevention, intervention, and care. As people live longer …
APOE in the bullseye of neurodegenerative diseases: impact of the APOE genotype in Alzheimer's disease pathology and brain diseases
R Fernández-Calle, SC Konings… - Molecular …, 2022 - Springer
ApoE is the major lipid and cholesterol carrier in the CNS. There are three major human
polymorphisms, apoE2, apoE3, and apoE4, and the genetic expression of APOE4 is one of …
polymorphisms, apoE2, apoE3, and apoE4, and the genetic expression of APOE4 is one of …
Impaired insulin signalling and allostatic load in Alzheimer disease
The discovery of insulin in 1921 revolutionized the treatment of diabetes and paved the way
for numerous studies on hormone signalling networks and actions in peripheral tissues and …
for numerous studies on hormone signalling networks and actions in peripheral tissues and …
Brain-gut axis dysfunction in the pathogenesis of traumatic brain injury
M Hanscom, DJ Loane… - The Journal of Clinical …, 2021 - Am Soc Clin Investig
Traumatic brain injury (TBI) is a chronic and progressive disease, and management requires
an understanding of both the primary neurological injury and the secondary sequelae that …
an understanding of both the primary neurological injury and the secondary sequelae that …
Understanding neurodegeneration after traumatic brain injury: from mechanisms to clinical trials in dementia
Traumatic brain injury (TBI) leads to increased rates of dementia, including Alzheimer's
disease. The mechanisms by which trauma can trigger neurodegeneration are increasingly …
disease. The mechanisms by which trauma can trigger neurodegeneration are increasingly …
Version 3 of the national Alzheimer's coordinating center's uniform data set
Methods: UDS Version 3 was developed after years of coordination between the National
Institute on Aging-appointed Clinical Task Force (CTF), clinicians from∼ 30 ADCs, and the …
Institute on Aging-appointed Clinical Task Force (CTF), clinicians from∼ 30 ADCs, and the …
[HTML][HTML] Promoting successful cognitive aging: a ten-year update
A decade has passed since we published a comprehensive review in this journal
addressing the topic of promoting successful cognitive aging, making this a good time to …
addressing the topic of promoting successful cognitive aging, making this a good time to …
Tau pathology in chronic traumatic encephalopathy and Alzheimer's disease: similarities and differences
A Katsumoto, H Takeuchi, F Tanaka - Frontiers in neurology, 2019 - frontiersin.org
Traumatic brain injury (TBI) has been associated with the development of Alzheimer's
disease (AD) because these conditions share common pathological hallmarks: amyloid-β …
disease (AD) because these conditions share common pathological hallmarks: amyloid-β …
Gene-environment interactions in Alzheimer's disease: a potential path to precision medicine
Alzheimer's disease (AD) is the leading cause of dementia in the United States and afflicts>
5.7 million Americans in 2018. Therapeutic options remain extremely limited to those that …
5.7 million Americans in 2018. Therapeutic options remain extremely limited to those that …
Chronic cortical inflammation, cognitive impairment, and immune reactivity associated with diffuse brain injury are ameliorated by forced turnover of microglia
Traumatic brain injury (TBI) is associated with an increased risk of cognitive, psychiatric, and
neurodegenerative complications that may develop after injury. Increased microglial …
neurodegenerative complications that may develop after injury. Increased microglial …