Schizophrenia is a leading cause of global disability. Current pharmacotherapy for the
disease predominantly uses one mechanism—dopamine D2 receptor blockade—but often …

The discovery of ketamine as a rapid-acting antidepressant spurred significant research to
understand its underlying mechanisms of action and to identify other novel compounds that …

Translating sensory inputs to perceptual decisions relies on building internal
representations of features critical for solving complex tasks. Yet, we still lack a mechanistic …

Background Subanesthetic ketamine has accumulated meta-analytic evidence for rapid
antidepressant effects in treatment-resistant depression (TRD), resulting in both excitement …

Stress represents a major risk factor for psychiatric disorders, including post-traumatic stress
disorder (PTSD). Recently, we dissected the destabilizing effects of acute stress on the …

Abstract Magnetic Resonance Spectroscopic Imaging (MRSI) of the brain enables insights
into the metabolic changes and fluxes in diseases such as tumors, multiple sclerosis …

Sex hormones affect the GABAergic and glutamatergic neurotransmitter system as
demonstrated in animal studies. However, human research has mostly been correlational in …

During the last 100 years, the role of anesthesiologists in psychiatry has focused primarily
on facilitating electroconvulsive therapy and mitigating postoperative delirium and other …

Schizophrenia is a serious neuropsychiatric disorder characterized by the presence of
positive symptoms (hallucinations, delusions, and disorganization of thought and language) …

Depression is a common, recurrent mental disorder and one of the leading causes of
disability and global burden of disease worldwide. Up to 15%-40% of cases do not respond …