Objective: To investigate and measure the functional significance of altered P2Y12
expression in the context of human microglia activation. Methods: We performed in vitro and …

Background Helminth infections and their components have been shown to have a
protective effect on autoimmune diseases. The isolated purified protein from Schisotosoma …

Background Schistosome eggs are trapped in host liver and elicit severe hepatic
granulomatous inflammation, which can lead to periportal fibrosis, portal hypertension …

Cyclophilins belong to the superfamily of peptidyl-prolyl cis/trans isomerases (PPIases, EC:
5.2. 1.8), the enzymes that catalyze the cis/trans isomerization of peptidyl-prolyl peptide …

The helminth Schistosoma mansoni modulates the infected host's immune system to
facilitate its own survival, by producing excretory/secretory molecules that interact with a …

The intraperitoneal cysticercosis model with the Taenia crassiceps ORF strain in female
BALB/cAnN mice has been widely used to study the immune response in cysticercosis …

Although dendritic cells (DCs) have been widely demonstrated to play essential roles in
initiation of Th2 responses in helminth infections and allergic reactions, the mechanisms …

Schistosomiasis japonicum is one of the most severe zoonotic diseases in China. Water
buffalo and yellow cattle are important reservoir hosts and the main transmission sources of …

Background Schistosomiasis is a chronic parasitic disease that affects approximately 200
million people. In Schistosomiasis japonica and mansoni, parasite eggs were trapped in …

Background It has been well accepted that glycans present in schistosomes are highly
antigenic. However, it is not clear what kind of worm glycans can affect the infected host to …