Signaling pathways involved in ischemic stroke: molecular mechanisms and therapeutic interventions

C Qin, S Yang, YH Chu, H Zhang, XW Pang… - Signal transduction and …, 2022 - nature.com
Ischemic stroke is caused primarily by an interruption in cerebral blood flow, which induces
severe neural injuries, and is one of the leading causes of death and disability worldwide …

Neuroinflammation as a key driver of secondary neurodegeneration following stroke?

SM Stuckey, LK Ong, LE Collins-Praino… - International Journal of …, 2021 - mdpi.com
Ischaemic stroke involves the rapid onset of focal neurological dysfunction, most commonly
due to an arterial blockage in a specific region of the brain. Stroke is a leading cause of …

[HTML][HTML] Actualización en diagnóstico y tratamiento del ataque cerebrovascular isquémico agudo

C García Alfonso, A Martínez Reyes, V García… - Universitas …, 2019 - scielo.org.co
El ataque cerebrovascular (ACV) agudo es la segunda causa de muerte en el mundo y
genera costos elevados en su tratamiento y recuperación, así como un gran impacto …

The association of neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, and lymphocyte to monocyte ratio with post-thrombolysis early neurological outcomes in …

P Gong, Y Liu, Y Gong, G Chen, X Zhang… - Journal of …, 2021 - Springer
Background and purpose To investigate the association of neutrophil to lymphocyte ratio
(NLR), platelet to lymphocyte ratio (PLR), and lymphocyte to monocyte ratio (LMR) with post …

Extracellular vesicles improve post-stroke neuroregeneration and prevent postischemic immunosuppression

TR Doeppner, J Herz, A Görgens… - Stem cells …, 2015 - academic.oup.com
Although the initial concepts of stem cell therapy aimed at replacing lost tissue, more recent
evidence has suggested that stem and progenitor cells alike promote postischemic …

Commensal microbiota affects ischemic stroke outcome by regulating intestinal γδ T cells

C Benakis, D Brea, S Caballero, G Faraco, J Moore… - Nature medicine, 2016 - nature.com
Commensal gut bacteria impact the host immune system and can influence disease
processes in several organs, including the brain. However, it remains unclear whether the …

MiR-155: an important regulator of neuroinflammation

VD Zingale, A Gugliandolo, E Mazzon - International Journal of Molecular …, 2021 - mdpi.com
MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate gene expression
at the post-transcriptional level and that play an important role in many cellular processes …

Prognostic value of neutrophil-to-lymphocyte ratio in stroke: a systematic review and meta-analysis

W Li, M Hou, Z Ding, X Liu, Y Shao, X Li - Frontiers in Neurology, 2021 - frontiersin.org
Background: Stroke has become a major problem around the world, which is one of the
main causes of long-term disability. Therefore, it is important to seek a biomarker to predict …

Depletion of microglia exacerbates postischemic inflammation and brain injury

WN **, SXY Shi, Z Li, M Li, K Wood… - Journal of Cerebral …, 2017 - journals.sagepub.com
Brain ischemia elicits microglial activation and microglia survival depend on signaling
through colony-stimulating factor 1 receptor (CSF1R). Although depletion of microglia has …

Treatments in ischemic stroke: current and future

MG Mosconi, M Paciaroni - European neurology, 2022 - karger.com
Abstract Background and Aim: Despite progress made over the last 30 years, stroke is still a
leading cause of disability and mortality; likewise, its burden is expected to increase over the …