Recent advances in systems and synthetic biology approaches for develo** novel cell-factories in non-conventional yeasts

P Patra, M Das, P Kundu, A Ghosh - Biotechnology Advances, 2021 - Elsevier
Microbial bioproduction of chemicals, proteins, and primary metabolites from cheap carbon
sources is currently an advancing area in industrial research. The model yeast …

Customized yeast cell factories for biopharmaceuticals: from cell engineering to process scale up

A Madhavan, KB Arun, R Sindhu… - Microbial Cell …, 2021 - Springer
The manufacture of recombinant therapeutics is a fastest-develo** section of therapeutic
pharmaceuticals and presently plays a significant role in disease management. Yeasts are …

Engineering peroxisomal biosynthetic pathways for maximization of triterpene production in Yarrowia lipolytica

Y Ma, Y Shang… - Proceedings of the …, 2024 - National Acad Sciences
Constructing efficient cell factories for product synthesis is frequently hampered by
competing pathways and/or insufficient precursor supply. This is particularly evident in the …

Genetic and bioprocess engineering to improve squalene production in Yarrowia lipolytica

H Liu, F Wang, L Deng, P Xu - Bioresource technology, 2020 - Elsevier
Squalene is the precursor for triterpene-based natural products and steroids-based drugs. It
has been widely used as pharmaceutical intermediates and personal care products. The …

Metabolic engineering of Yarrowia lipolytica for improving squalene production

WY Tang, DP Wang, Y Tian, X Fan, C Wang… - Bioresource …, 2021 - Elsevier
The aim of this present research is to enhance the squalene production in Yarrowia
lipolytica using pathway engineering and bioprocess engineering. Firstly, to improve the …

Metabolic engineering of Yarrowia lipolytica for terpenoids production: advances and perspectives

G Zhang, H Wang, Z Zhang, KJ Verstrepen… - Critical Reviews in …, 2022 - Taylor & Francis
Terpenoids are a large family of natural products with diversified structures and functions
that are widely used in the food, pharmaceutical, cosmetic, and agricultural fields. However …

Metabolic engineering of Yarrowia Lipolytica for high-level production of squalene

Z Liu, M Huang, H Chen, X Lu, Y Tian, P Hu… - Bioresource …, 2024 - Elsevier
Squalene is an important triterpene with a wide range of applications. Given the growing
market demand for squalene, the development of microbial cell factories capable of …

Yarrowia lipolytica Strains Engineered for the Production of Terpenoids

JA Arnesen, KR Kildegaard… - … in Bioengineering and …, 2020 - frontiersin.org
Terpenoids are a diverse group of over 55,000 compounds with potential applications as
advanced fuels, bulk and fine chemicals, pharmaceutical ingredients, agricultural chemicals …

Advanced Strategies for the Synthesis of Terpenoids in Yarrowia lipolytica

ZJ Li, YZ Wang, LR Wang, TQ Shi… - Journal of Agricultural …, 2021 - ACS Publications
Terpenoids are an important class of secondary metabolites that play an important role in
food, agriculture, and other fields. Microorganisms are rapidly emerging as a promising …

Metabolic Engineering of Yarrowia lipolytica for Terpenoid Production: Tools and Strategies

TL Zhang, HW Yu, LD Ye - ACS Synthetic Biology, 2023 - ACS Publications
Terpenoids are a diverse group of compounds with isoprene units as basic building blocks.
They are widely used in the food, feed, pharmaceutical, and cosmetic industries due to their …