Neuroimmunology of traumatic brain injury: time for a paradigm shift

YN Jassam, S Izzy, M Whalen, DB McGavern… - Neuron, 2017 - cell.com
Traumatic brain injury (TBI) is a leading cause of morbidity and disability, with a
considerable socioeconomic burden. Heterogeneity of pathoanatomical subtypes and …

Guidelines for the management of pediatric severe traumatic brain injury: update of the brain trauma foundation guidelines

PM Kochanek, RC Tasker, N Carney… - Pediatric Critical Care …, 2019 - journals.lww.com
Any opinions, findings, and conclusions or recommendations expressed in this material are
those of the authors and do not necessarily reflect the views of the US Army Contracting …

Increased miR‐124‐3p in microglial exosomes following traumatic brain injury inhibits neuronal inflammation and contributes to neurite outgrowth via their transfer …

S Huang, X Ge, J Yu, Z Han, Z Yin, Y Li… - The FASEB …, 2018 - Wiley Online Library
Neuronal inflammation is the characteristic pathologic change of acute neurologic
impairment and chronic traumatic encephalopathy after traumatic brain injury (TBI) …

The Glasgow Coma Scale at 40 years: standing the test of time

G Teasdale, A Maas, F Lecky, G Manley… - The Lancet …, 2014 - thelancet.com
Summary Since 1974, the Glasgow Coma Scale has provided a practical method for
bedside assessment of impairment of conscious level, the clinical hallmark of acute brain …

Acute management of traumatic brain injury

MA Vella, ML Crandall, MB Patel - Surgical Clinics, 2017 - surgical.theclinics.com
Trauma is the leading cause of death in individuals aged 1 to 45 years, with traumatic brain
injury (TBI) responsible for most these deaths; more than 50,000 deaths per year in the …

The systemic immune response to trauma: an overview of pathophysiology and treatment

JM Lord, MJ Midwinter, YF Chen, A Belli, K Brohi… - The Lancet, 2014 - thelancet.com
Improvements in the control of haemorrhage after trauma have resulted in the survival of
many people who would otherwise have died from the initial loss of blood. However, the …

Chronic impact of traumatic brain injury on outcome and quality of life: a narrative review

N Stocchetti, ER Zanier - Critical Care, 2016 - Springer
Traditionally seen as a sudden, brutal event with short-term impairment, traumatic brain
injury (TBI) may cause persistent, sometimes life-long, consequences. While mortality after …

Revisiting traumatic brain injury: from molecular mechanisms to therapeutic interventions

A Jarrahi, M Braun, M Ahluwalia, RV Gupta, M Wilson… - Biomedicines, 2020 - mdpi.com
Studying the complex molecular mechanisms involved in traumatic brain injury (TBI) is
crucial for develo** new therapies for TBI. Current treatments for TBI are primarily focused …

Inflammatory neuroprotection following traumatic brain injury

MV Russo, DB McGavern - Science, 2016 - science.org
Traumatic brain injury (TBI) elicits an inflammatory response in the central nervous system
(CNS) that involves both resident and peripheral immune cells. Neuroinflammation can …

Cost of disorders of the brain in Europe 2010

A Gustavsson, M Svensson, F Jacobi… - European …, 2011 - Elsevier
BACKGROUND: The spectrum of disorders of the brain is large, covering hundreds of
disorders that are listed in either the mental or neurological disorder chapters of the …