The role of astrocytic glutamate transporters GLT-1 and GLAST in neurological disorders: Potential targets for neurotherapeutics

E Pajarillo, A Rizor, J Lee, M Aschner, E Lee - Neuropharmacology, 2019 - Elsevier
Glutamate is the primary excitatory neurotransmitter in the central nervous system (CNS)
which initiates rapid signal transmission in the synapse before its re-uptake into the …

The regulation of astrocytic glutamate transporters in health and neurodegenerative diseases

AC Todd, GE Hardingham - International journal of molecular sciences, 2020 - mdpi.com
The astrocytic glutamate transporters excitatory amino acid transporters 1 and 2 (EAAT1 and
EAAT2) play a key role in nervous system function to maintain extracellular glutamate levels …

The meteorology of cytokine storms, and the clinical usefulness of this knowledge

IA Clark, B Vissel - Seminars in immunopathology, 2017 - Springer
The term cytokine storm has become a popular descriptor of the dramatic harmful
consequences of the rapid release of polypeptide mediators, or cytokines, that generate …

Glutamate transport and preterm brain injury

S Pregnolato, E Chakkarapani, AR Isles… - Frontiers in …, 2019 - frontiersin.org
Preterm birth complications are the leading cause of child death worldwide and a top global
health priority. Among the survivors, the risk of life-long disabilities is high, including cerebral …

Insights from genetic studies of cerebral palsy

SA Lewis, S Shetty, BA Wilson, AJ Huang… - Frontiers in …, 2021 - frontiersin.org
Cohort-based whole exome and whole genome sequencing and copy number variant
(CNV) studies have identified genetic etiologies for a sizable proportion of patients with …

Definition and diagnosis of cerebral palsy in genetic studies: a systematic review

R Pham, BW Mol, J Gecz… - … Medicine & Child …, 2020 - Wiley Online Library
Aim To conduct a systematic review of phenotypic definition and case ascertainment in
published genetic studies of cerebral palsy (CP) to inform guidelines for the reporting of …

[HTML][HTML] Cerebral Palsy as a Childhood-onset Neurologic Disorder caused by both genetic and environmental factors.

NG Sandran, N Badawi, J Gecz, CL van Eyk - Seminars in Fetal and …, 2024 - Elsevier
Cerebral palsy (CP) is a clinical term used to describe a spectrum of movement and posture
disorders resulting from non-progressive disturbances in the develo** fetal brain. The …

Variants of the OLIG2 Gene are Associated with Cerebral Palsy in Chinese Han Infants with Hypoxic–Ischemic Encephalopathy

L Sun, L **a, M Wang, D Zhu, Y Wang, D Bi… - NeuroMolecular …, 2019 - Springer
Cerebral palsy (CP) is a leading cause of neurological disability among young children.
Congenial and adverse perinatal clinical conditions, such as genetic factors, perinatal …

Neonatal brain injury and genetic causes of adult-onset neurodegenerative disease in mice interact with effects on acute and late outcomes

LJ Martin, M Wong, A Hanaford - Frontiers in Neurology, 2019 - frontiersin.org
Neonatal brain damage and age-related neurodegenerative disease share many common
mechanisms of injury involving mitochondriopathy, oxidative stress, excitotoxicity …

Pharmacological neuroprotection of the preterm brain: current evidence and perspectives

T Siahanidou, C Spiliopoulou - American Journal of …, 2022 - thieme-connect.com
Despite improvements in viability, the long-term neurodevelopmental outcomes of preterm
babies remain serious concern as a significant percentage of these infants develop …