The mystical experience is a potential psychological mechanism to influence outcome in
psychedelic therapy. It includes features such as oceanic boundlessness, ego dissolution …

This paper provides a critical review of several possible mechanisms at different levels of
analysis underlying the effects and therapeutic potential of psychedelics. At the (1) …

A single dose of psilocybin, a psychedelic that acutely causes distortions of space–time
perception and ego dissolution, produces rapid and persistent therapeutic effects in human …

Psychedelics have attracted medical interest, but their effects on human brain function are
incompletely understood. In a comprehensive, within-subjects, placebo-controlled design …

Background: Preliminary data suggest that psilocybin-assisted treatment produces
substantial and rapid antidepressant effects in patients with major depressive disorder …

Classic psychedelics produce altered states of consciousness that individuals often interpret
as meaningful experiences. Across a number of human studies, when the participant-rated …

Objective: The authors provide an evidenced-based summary of the literature on the clinical
application of psychedelic drugs in psychiatric disorders. Methods: Searches of PubMed and …

Growing interest has been seen in using lysergic acid diethylamide (LSD) and psilocybin in
psychiatric research and therapy. However, no modern studies have evaluated differences …

Background: Several early phase studies have demonstrated that psilocybin-assisted
therapy has rapid-acting and persisting antidepressant effects from just one or two doses …

The purpose of this paper is to provide an integrative review and offer novel insights
regarding human research with classic psychedelics (classic hallucinogens), which are …