Nanosuspensions have garnered recent attention as a promising strategy for mitigating the
bioavailability challenges of hydrophobic drugs, particularly those characterized by poor …

Since the emergence of Soluplus®(SOL) as a commercial graft copolymer, several
publications have been issued on its promising potential as a solubilizing excipient that …

Vertical stirred mills have become increasingly popular in size reduction operations in the
fine and ultrafine range, being normally used in industry in continuous operation. The …

Wet media milling is a popular technology used to prepare nanosuspensions. However, the
theories and methods to guide the research on the formulation and process affecting wet …

An industrial-scale vertical wet stirred media mill (HIGMill) was simulated via a population
balance model (PBM). Feed and product particle size distributions (PSDs) of copper ore …

This study aimed to develop a practical semi-mechanistic modeling framework to predict
particle size evolution during wet bead milling of pharmaceutical nanosuspensions over a …

The work uses the UFRJ mechanistic mill model and DEM to analyze the effect of several
design and operating variables on the apparent breakage rates and breakage distribution …

Lutein has limited applicability in the food industry because of its poor water solubility and
chemical instability. In this study, amorphous and crystalline lutein-loaded …

Although heat is generated during the wet stirred media milling of drug suspensions, leading
to notable temperature rise, a comprehensive analysis of heat generation does not exist …

Qualitative description of stressing energies between grinding beads/media in wet stirred
media mills at different operation settings could provide a comprehensive understanding of …