Alzheimer's disease (AD) is the most common neurodegenerative disease, which severely
threatens the health of the elderly and causes significant economic and social burdens. The …

Autism spectrum disorders (ASD) are neurodevelopmental disorders typically diagnosed in
childhood, characterized by core social dysfunction, rigid and repetitive behaviors, restricted …

Accumulating evidence suggests that epigenetic alterations in brain-derived neurotrophic
factor (BDNF) promoters are associated with the pathophysiology of psychiatric disorders …

Advanced paternal age can have deleterious effects on various traits in the next generation.
Here, we establish a paternal‐aging model in mice to understand the molecular …

REST [RE1-silencing transcription factor (also called neuron-restrictive silencer factor)] is
known to repress thousands of possible target genes, many of which are neuron specific. To …

Mounting evidence indicates that soluble oligomeric forms of amyloid proteins linked to
neurodegenerative disorders, such as amyloid-β (Aβ), tau, or α-synuclein (αSyn) might be …

Neuroinflammation is associated with synapse dysfunction and cognitive decline in patients
and animal models. One candidate for translating the inflammatory stress into structural and …

Background REST (Repressor‐Element 1 [RE1]‐silencing transcription factor) inhibits
Na+/Ca2+ exchanger‐1 (Ncx1) transcription in neurons through the binding of RE1 site on …

The RE-1 silencing transcription factor (REST) is a repressor factor related to
neuroendocrine prostate cancer (PCa)(NEPC), a poor prognostic stage mainly associated …

Directed differentiation of serotonin neurons (SNs) from human pluripotent stem cells
(hPSCs) provides a valuable tool for uncovering the mechanism of human SN development …