Alcohol use disorders consist of disorders characterised by compulsive heavy alcohol use
and loss of control over alcohol intake. Alcohol use disorders are some of the most prevalent …

Alcohol use disorder (AUD) is a highly prevalent, comorbid, and disabling disorder. The
underlying mechanism of ethanol neurotoxicity and the involvement of oxidative stress is still …

Background: Whether the positive associations of smoking and alcohol consumption with
gastrointestinal diseases are causal is uncertain. We conducted this Mendelian …

Tobacco and alcohol use are leading causes of mortality that influence risk for many
complex diseases and disorders. They are heritable, and etiologically related, behaviors that …

Objective: Alcohol use disorders are common conditions that have enormous social and
economic consequences. Genome-wide association analyses were performed to identify …

Substance use disorders (SUDs) are prevalent and result in an array of negative
consequences. They are influenced by genetic factors (h2=~ 50%). Recent years have …

Objective To determine which potentially modifiable risk factors, including socioeconomic,
lifestyle/dietary, cardiometabolic, and inflammatory factors, are associated with Alzheimer's …

Alcohol use disorders (AUDs) are complex traits, meaning that variations in many genes
contribute to the risk, as does the environment. Although the total genetic contribution to risk …

Purpose of Review A clear link between excessive alcohol consumption and cardiovascular
disease (CVD) has been established, but no consensus exists on the effects of moderate …

Unhealthful dietary habits are leading risk factors for life-altering diseases and mortality.
Large-scale biobanks now enable genetic analysis of traits with modest heritability, such as …