The complement system: an unexpected role in synaptic pruning during development and disease

AH Stephan, BA Barres… - Annual review of …, 2012 - annualreviews.org
An unexpected role for the classical complement cascade in the elimination of central
nervous system (CNS) synapses has recently been discovered. Complement proteins are …

The role of the novel adipocyte-derived hormone adiponectin in human disease

JJ Diez, P Iglesias - European Journal of endocrinology, 2003 - academic.oup.com
Abstract Adiponectin, also called GBP-28, apM1, AdipoQ and Acrp30, is a novel adipose
tIssue-specific protein that has structural homology to collagen VIII and X and complement …

Complement is activated by IgG hexamers assembled at the cell surface

CA Diebolder, FJ Beurskens, RN De Jong, RI Koning… - Science, 2014 - science.org
Complement activation by antibodies bound to pathogens, tumors, and self antigens is a
critical feature of natural immune defense, a number of disease processes, and …

[書籍][B] Wintrobe's clinical hematology

MM Wintrobe - 2008 - books.google.com
Now available in a thoroughly revised Twelfth Edition, Wintrobe's Clinical Hematology
continues to be an industry leader with its ability to correlate basic science with the clinical …

Adipo‐myokines: Two sides of the same coin—Mediators of inflammation and mediators of exercise

S Raschke, J Eckel - Mediators of inflammation, 2013 - Wiley Online Library
This review summarizes the current literature regarding the most discussed contraction‐
regulated moykines like IL‐6, IL‐15, irisin, BDNF, ANGPTL4, FGF21, myonectin and MCP‐1 …

ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism

AH Berg, TP Combs, PE Scherer - Trends in Endocrinology & Metabolism, 2002 - cell.com
In recent years, we have learned that adipocytes are not merely inert storage depots for
triglycerides but rather highly active cells with potent autocrine, paracrine and endocrine …

The molecular architecture of the TNF superfamily

JL Bodmer, P Schneider, J Tschopp - Trends in biochemical sciences, 2002 - cell.com
Ligands of the TNF (tumour necrosis factor) superfamily have pivotal roles in the
organization and function of the immune system, and are implicated in the aetiology of …

Preclinical Activity of the Type II CD20 Antibody GA101 (Obinutuzumab) Compared with Rituximab and Ofatumumab In Vitro and in Xenograft Models

S Herter, F Herting, O Mundigl, I Waldhauer… - Molecular cancer …, 2013 - AACR
We report the first preclinical in vitro and in vivo comparison of GA101 (obinutuzumab), a
novel glycoengineered type II CD20 monoclonal antibody, with rituximab and ofatumumab …

Recent advances on the complement system of teleost fish

H Boshra, J Li, JO Sunyer - Fish & shellfish immunology, 2006 - Elsevier
The complement system plays an essential role in alerting the host of the presence of
potential pathogens, as well as in their clearing. In addition, activation of the complement …

Evolution of the lectin–complement pathway and its role in innate immunity

T Fujita - Nature Reviews Immunology, 2002 - nature.com
Discrimination between self and non-self by lectins (carbohydrate-binding proteins) is a
strategy of innate immunity that is found in both vertebrates and invertebrates. In vertebrates …