Turnover of cellular proteins is regulated by Ubiquitin Proteasome System (UPS).
Components of this pathway, including the proteasome, ubiquitinating enzymes and …

Herpesvirus-associated ubiquitin-specific protease (HAUSP) is a USP family deubiquitinase.
HAUSP is a protein of immense biological importance as it is involved in several cellular …

The MYCN proto-oncogene is amplified in a number of advanced-stage human tumors, such
as neuroblastomas. Similar to other members of the MYC family of oncoproteins, MYCN …

The histone demethylase PHF8 has been implicated in multiple pathological disorders,
including X-linked mental retardation and tumorigenesis. However, it is not clear how the …

Ubiquitin specific protease 7 (USP7) is one of the deubiquitinating enzymes (DUB) that
erases ubiquitin and protects substrate protein from degradation. Full activity of USP7 …

The large family of deubiquitinating enzymes (DUBs) are involved in the regulation of a
plethora of processes carried out inside the cell by protein ubiquitination. Ubiquitination is a …

Kaposi sarcoma herpesvirus (KSHV), taxonomical name human gammaherpesvirus 8, is a
phylogenetically old human virus that co-evolved with human populations, but is now only …

Deubiquitinases (DUBs) play important roles and therefore are potential drug targets in
various diseases including cancer and neurodegeneration. In this review, we recapitulate …

Kaposi's sarcoma-associated herpesvirus (KSHV) primarily persists as a latent episome in
infected cells. During latent infection, only a limited number of viral genes are expressed that …

Highlights•KSHV/HHV8 causes three human diseases: Kaposi Sarcoma, Primary Effusion
Lymphoma and the plasma cell variant of Multicentric Castleman Disease.•These occur …