Human prion diseases: surgical lessons learned from iatrogenic prion transmission
The human prion diseases, or transmissible spongiform encephalopathies, have captivated
our imaginations since their discovery in the Fore linguistic group in Papua New Guinea in …
our imaginations since their discovery in the Fore linguistic group in Papua New Guinea in …
The influence of PRNP polymorphisms on human prion disease susceptibility: an update
Two normally occurring polymorphisms of the human PRNP gene, methionine (M)/valine (V)
at codon 129 and glutamic acid (E)/lysine (K) at codon 219, can affect the susceptibility to …
at codon 129 and glutamic acid (E)/lysine (K) at codon 219, can affect the susceptibility to …
Application of yeast to studying amyloid and prion diseases
Amyloids are fibrous cross-β protein aggregates that are capable of proliferation via
nucleated polymerization. Amyloid conformation likely represents an ancient protein fold …
nucleated polymerization. Amyloid conformation likely represents an ancient protein fold …
Role of the Goat K222-PrPC Polymorphic Variant in Prion Infection Resistance
The prion protein-encoding gene (prnp) strongly influences the susceptibility of small
ruminants to transmissible spongiform encephalopathies (TSEs). Hence, selective breeding …
ruminants to transmissible spongiform encephalopathies (TSEs). Hence, selective breeding …
Deciphering the pathogenesis of sporadic Creutzfeldt-Jakob disease with codon 129 M/V and type 2 abnormal prion protein
A Kobayashi, Y Iwasaki, H Otsuka, M Yamada… - Acta neuropathologica …, 2013 - Springer
Abstract Background Sporadic Creutzfeldt-Jakob disease is classified according to the
genotype at polymorphic codon 129 (M or V) of the prion protein (PrP) gene and the type (1 …
genotype at polymorphic codon 129 (M or V) of the prion protein (PrP) gene and the type (1 …
Protective V127 prion variant prevents prion disease by interrupting the formation of dimer and fibril from molecular dynamics simulations
S Zhou, D Shi, X Liu, H Liu, X Yao - Scientific Reports, 2016 - nature.com
Recent studies uncovered a novel protective prion protein variant: V127 variant, which was
reported intrinsically resistant to prion conversion and propagation. However, the structural …
reported intrinsically resistant to prion conversion and propagation. However, the structural …
Effects of polymorphisms in ovine and caprine prion protein alleles on cell-free conversion
M Eiden, EO Soto, TC Mettenleiter, MH Groschup - Veterinary Research, 2011 - Springer
In sheep polymorphisms of the prion gene (PRNP) at the codons 136, 154 and 171 strongly
influence the susceptibility to scrapie and bovine spongiform encephalopathy (BSE) …
influence the susceptibility to scrapie and bovine spongiform encephalopathy (BSE) …
A domain responsible for spontaneous conversion of bank vole prion protein
A Kobayashi, Y Matsuura, A Takeuchi… - Brain …, 2019 - Wiley Online Library
Bank vole is a small rodent that shows high susceptibility to infection with diverse prion
strains. To determine whether the increased susceptibility of bank voles to prion diseases …
strains. To determine whether the increased susceptibility of bank voles to prion diseases …
Identification of polymorphisms in the ovine Shadow of prion protein (SPRN) gene and assessment of their effect on promoter activity and susceptibility for classical …
Shadow of prion protein (SPRN) is an interesting candidate gene thought to be involved in
prion pathogenesis. In humans, an association has already been discovered between …
prion pathogenesis. In humans, an association has already been discovered between …
Novel polymorphisms in ovine prion protein gene
The aim of this study was to identify the PRNP polymorphisms outside the standard codons
136, 154 and 171 in 1110 sheep with no clinical sign of scrapie from all 18 T urkish native …
136, 154 and 171 in 1110 sheep with no clinical sign of scrapie from all 18 T urkish native …