One of the most widely conserved hallmarks of aging is a decline in functional capabilities.
Mobility loss is particularly burdensome due to its association with negative health …

Dementia is characterized by a long preclinical phase that may last years to decades before
the onset of mild cognitive impairment. Slow gait speed and subjective memory complaint …

Background Although slow gait speed is an established risk factor for falls, few studies have
evaluated change in gait speed as a predictor of falls or considered variability in effects by …

Importance Gait speed is a well-known indicator of risk of functional decline and mortality in
older adults, but little is known about the factors associated with gait speed earlier in life …

Introduction In this longitudinal study, we aimed to examine if slowing gait speed preceded
cognitive decline and correlated with brain amyloidosis. Methods The sample (n= 287) was …

Background This study aimed to investigate the associations of sarcopenia and its defining
components with cognitive function in community-dwelling oldest old (over 80 years old) in …

Background: Measures of handgrip strength have not only emerged as a clinically viable
screening tool for determining risk for morbidity, functional disability, and early mortality, but …

Background Prior work suggests there may be greater reliance on executive function for
walking in older people. The pre-frontal cortex (PFC), which controls aspects of executive …

Objectives Very few studies looking at slow gait speed as early marker of cognitive decline
investigated the competing risk of death. The current study examines associations between …

Importance Dual decline in both memory and gait speed may characterize a group of older
individuals at high risk for future dementia. Objective To assess the risk of dementia in older …