Protein crucial function and flexibility directly depend on its whole structure which is
determined by the native distribution of structural elements. Any disturbances in a protein …

The extraordinary ligand binding properties of albumin makes it a key player in the
pharmacokinetics and pharmacodynamics of many vital drugs. Albumin is highly susceptible …

Aims/hypothesis Diabetic peripheral neuropathy (DN) is a common complication of diabetes;
however, the mechanisms producing positive or negative symptoms are not well …

Advanced glycation endproducts (AGEs) have been implicated in the pathogenesis of
cancer, inflammatory conditions and diabetic complications. An interaction of AGEs with their …

Geroprotectors are drugs that decrease the rate of aging and therefore extend life span.
Metformin has been described as a geroprotector, and several studies have shown that …

Glycation is one of the major processes responsible for skin aging through induction of the
detrimental formation of advanced glycation end-products (AGEs). We developed an …