Inflammation may be defined as the innate response to harmful stimuli such as pathogens,
injury, and metabolic stress; its ultimate function is to restore the physiological homeostatic …

Type 2 diabetes mellitus (T2DM), accounting for 90–95% cases of diabetes, is characterized
by chronic inflammation. The mechanisms that control inflammation activation in T2DM are …

Diabetes aggravates myocardial ischemia‐reperfusion (I/R) injury because of the
combination effects of changes in glucose and lipid energy metabolism, oxidative stress …

The NLRP3 inflammasome responds to infection and tissue damage, and rapidly escalates
the intensity of inflammation by activating interleukin (IL)-1β, IL-18 and cell death by …

Inflammation is closely associated with obesity and related metabolic disorders. However, its
origin during obesity is largely unknown. Here, we report that ubiquitin-conjugating enzyme …

Ulcerative colitis (UC) is an inflammatory bowel disease (IBD) with chronic and recurrent
characteristics caused by multiple reasons. Although the pathogenic factors have not been …

The NLRP3 inflammasome is an intracellular innate immune sensor that is expressed in
immune cells, including monocytes and macrophages. Activation of the NLRP3 …

Chikungunya virus (CHIKV) is an arthropod-borne virus (arbovirus) of epidemic concern,
transmitted by Aedes ssp. mosquitoes, and is the etiologic agent of a febrile and …

Inflammasomes, key molecular regulators that play an important role in inflammation, consist
of a central protein, an adaptor protein ASC (apoptosis speck-like protein) and a caspase-1 …

Non-alcoholic fatty liver disease (NAFLD) is characterized by excessive storage of fatty acids
in the form of triglycerides in hepatocytes. It is most prevalent in western countries and …