Cardiac and skeletal striated muscles are intricately designed machines responsible for
muscle contraction. Coordination of the basic contractile unit, the sarcomere, and the …

The giant sarcomere protein titin is a major determinant of cardiomyocyte stiffness and
contributor to cardiac strain sensing. Titin-based forces are highly regulated in health and …

Single-molecule atomic force microscopy (AFM) was used to investigate the mechanical
properties of titin, the giant sarcomeric protein of striated muscle. Individual titin molecules …

The giant protein titin forms a unique filament network in cardiomyocytes, which engages in
both mechanical and signaling functions of the heart. TTN, which encodes titin, is also a …

Titin, a giant filamentous polypeptide, is believed to play a fundamental role in maintaining
sarcomeric structural integrity and develo** what is known as passive force in muscle …

Contractile and energetic properties of human skeletal muscle have been studied for many
years in vivo in the body. It has been, however, difficult to identify the specific role of muscle …

▪ Abstract Mechanical processes are involved in nearly every facet of the cell cycle.
Mechanical forces are generated in the cell during processes as diverse as chromosomal …

The purpose of this article was to review the literature on passive extensibility of skeletal
muscle with reference to its anatomic and physiologic properties, mechanisms of …

Muscles operate eccentrically to either dissipate energy for decelerating the body or to store
elastic recoil energy in preparation for a shortening (concentric) contraction. The muscle …

Titin is a filamentous protein spanning the half-sarcomere, with spring-like properties in the I-
band region. Various structural, signaling, and mechanical functions have been associated …