Small interfering RNAs in the management of human osteoporosis

G Gargano, G Asparago, F Spiezia, F Oliva… - British Medical …, 2023 - academic.oup.com
Background Osteoporosis results in reduced bone mass and consequent bone fragility.
Small interfering RNAs (siRNAs) can be used for therapeutic purposes, as molecular targets …

Proximal femoral fractures in the elderly: a few things to know, and some to forget

N Maffulli, R Aicale - Medicina, 2022 - mdpi.com
Hip fractures are a leading cause of hospitalisation in elderly patients, representing an
increasing socioeconomic problem arising from demographic changes, considering the …

Predictors of osteoporotic fracture in postmenopausal women: a meta-analysis

G Long, C Liu, T Liang, Z Zhang, Z Qin… - Journal of Orthopaedic …, 2023 - Springer
Osteoporosis affects more than 200 million women worldwide, with postmenopausal women
being particularly susceptible to this condition and its severe sequelae disproportionately …

Expert consensus on the bone repair strategy for osteoporotic fractures in China

H Zhang, Y Hu, X Chen, S Wang, L Cao… - Frontiers in …, 2022 - frontiersin.org
Osteoporotic fractures, also known as fragility fractures, are prevalent in the elderly and
bring tremendous social burdens. Poor bone quality, weak repair capacity, instability, and …

Asperuloside alleviates osteoporosis by promoting autophagy and regulating Nrf2 activation

F Huang, Y Wang, J Liu, Y Cheng, X Zhang… - Journal of Orthopaedic …, 2024 - Springer
Background Osteoporosis is a metabolic bone disease that has a common occurrence in
postmenopausal women. Asperuloside (ASP) has been reported to exert anti-inflammatory …

Association between polymorphisms of glucagon-like peptide-1 receptor gene and susceptibility to osteoporosis in Chinese postmenopausal women

X Bao, C Liu, H Liu, Y Wang, P Xue, Y Li - Journal of Orthopaedic Surgery …, 2024 - Springer
Background The influence of the glucagon-like peptide-1 receptor (GLP-1R) on bone
metabolism is well-established. However, it has been observed that single nucleotide …

Bioinformatics and machine learning were used to validate glutamine metabolism-related genes and immunotherapy in osteoporosis patients

L Wang, C Deng, Z Wu, K Zhu, Z Yang - Journal of Orthopaedic Surgery …, 2023 - Springer
Background Osteoporosis (OP), often referred to as the “silent disease of the twenty-first
century,” poses a significant public health concern due to its severity, chronic nature, and …

Vertebroplasty for painful osteoporotic vertebral compression fractures: a protocol for a single-center doubled-blind randomized sham-controlled clinical trial. VOPE2

MØ Andersen, AK Andresen, J Hartvigsen… - Journal of Orthopaedic …, 2024 - Springer
Background One in three women and one in five men over the age of 50 will experience an
osteoporotic fracture. Vertebral fractures can be very painful, affect patients' daily function …

Comparison between calcaneus quantitative ultrasound and the gold standard DXA in the ability to detect osteoporosis in chronic obstructive pulmonary disease …

W Chanprasertpinyo, C Punsawad… - Journal of Orthopaedic …, 2023 - Springer
Background Osteoporosis is a prevalent comorbidity in patients with COPD that is usually
underrecognized and hence, undertreated. Compared to the gold standard dual-energy X …

Comparative performance analysis of large language models: ChatGPT-3.5, ChatGPT-4 and Google Gemini in glucocorticoid-induced osteoporosis

L Tong, C Zhang, R Liu, J Yang, Z Sun - Journal of Orthopaedic Surgery …, 2024 - Springer
Backgrounds The use of large language models (LLMs) in medicine can help physicians
improve the quality and effectiveness of health care by increasing the efficiency of medical …