Molecular responses to acute exercise and their relevance for adaptations in skeletal muscle to exercise training

B Egan, AP Sharples - Physiological Reviews, 2023 - journals.physiology.org
Repeated, episodic bouts of skeletal muscle contraction undertaken frequently as structured
exercise training are a potent stimulus for physiological adaptation in many organs …

Hallmarks of response, resistance, and toxicity to immune checkpoint blockade

G Morad, BA Helmink, P Sharma, JA Wargo - Cell, 2021 - cell.com
Unprecedented advances have been made in cancer treatment with the use of immune
checkpoint blockade (ICB). However, responses are limited to a subset of patients, and …

Health and disease markers correlate with gut microbiome composition across thousands of people

O Manor, CL Dai, SA Kornilov, B Smith… - Nature …, 2020 - nature.com
Variation in the human gut microbiome can reflect host lifestyle and behaviors and influence
disease biomarker levels in the blood. Understanding the relationships between gut …

Understanding the role of the gut microbiome and microbial metabolites in non-alcoholic fatty liver disease: current evidence and perspectives

N Vallianou, GS Christodoulatos, I Karampela… - Biomolecules, 2021 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease
worldwide. NAFLD begins as a relatively benign hepatic steatosis which can evolve to non …

[HTML][HTML] Exercise induces tissue-specific adaptations to enhance cardiometabolic health

SP Ashcroft, B Stocks, B Egan, JR Zierath - Cell metabolism, 2024 - cell.com
The risk associated with multiple cancers, cardiovascular disease, diabetes, and all-cause
mortality is decreased in individuals who meet the current recommendations for physical …

The connection between physical exercise and gut microbiota: implications for competitive sports athletes

AE Wegierska, IA Charitos, S Topi, MA Potenza… - Sports Medicine, 2022 - Springer
Gut microbiota refers to those microorganisms in the human digestive tract that display
activities fundamental in human life. With at least 4 million different bacterial types, the gut …

From gut microbiota to host appetite: gut microbiota-derived metabolites as key regulators

H Han, B Yi, R Zhong, M Wang, S Zhang, J Ma, Y Yin… - Microbiome, 2021 - Springer
Feelings of hunger and satiety are the key determinants for maintaining the life of humans
and animals. Disturbed appetite control may disrupt the metabolic health of the host and …

[HTML][HTML] Interplay between exercise and gut microbiome in the context of human health and performance

M Clauss, P Gérard, A Mosca, M Leclerc - Frontiers in nutrition, 2021 - frontiersin.org
Gut microbiota and exercise have recently been shown to be interconnected. Both moderate
and intense exercise are typically part of the training regimen of endurance athletes, but they …

[HTML][HTML] The compelling link between physical activity and the body's defense system

DC Nieman, LM Wentz - Journal of sport and health science, 2019 - Elsevier
This review summarizes research discoveries within 4 areas of exercise immunology that
have received the most attention from investigators:(1) acute and chronic effects of exercise …

Toward an improved definition of a healthy microbiome for healthy aging

TS Ghosh, F Shanahan, PW O'Toole - Nature Aging, 2022 - nature.com
The gut microbiome is a modifier of disease risk because it interacts with nutrition,
metabolism, immunity and infection. Aging-related health loss has been correlated with …