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Inhibition of bromodomain and extra-terminal proteins (BET) as a potential therapeutic approach in haematological malignancies: emerging preclinical and clinical …
Post-translational modifications of the nucleosomal histone proteins orchestrate chromatin
organization and gene expression in normal and cancer cells. Among them, the acetylation …
organization and gene expression in normal and cancer cells. Among them, the acetylation …
Ready, pause, go: regulation of RNA polymerase II pausing and release by cellular signaling pathways
Promoter-proximal pausing by RNA polymerase II (Pol II) is a well-established mechanism to
control the timing, rate, and possibly the magnitude of transcriptional responses. Recent …
control the timing, rate, and possibly the magnitude of transcriptional responses. Recent …
LncBRM initiates YAP1 signalling activation to drive self-renewal of liver cancer stem cells
Liver cancer stem cells (CSCs) may contribute to the high rate of recurrence and
heterogeneity of hepatocellular carcinoma (HCC). However, the biology of hepatic CSCs …
heterogeneity of hepatocellular carcinoma (HCC). However, the biology of hepatic CSCs …
Capturing the interactome of newly transcribed RNA
We combine the labeling of newly transcribed RNAs with 5-ethynyluridine with the
characterization of bound proteins. This approach, named capture of the newly transcribed …
characterization of bound proteins. This approach, named capture of the newly transcribed …
DNA methylation directs microRNA biogenesis in mammalian cells
MicroRNA (miRNA) biogenesis initiates co-transcriptionally, but how the Microprocessor
machinery pinpoints the locations of short precursor miRNA sequences within long flanking …
machinery pinpoints the locations of short precursor miRNA sequences within long flanking …
lncRNA DIGIT and BRD3 protein form phase-separated condensates to regulate endoderm differentiation
Cooperation between DNA, RNA and protein regulates gene expression and controls
differentiation through interactions that connect regions of nucleic acids and protein domains …
differentiation through interactions that connect regions of nucleic acids and protein domains …
The p53-induced lincRNA-p21 derails somatic cell reprogramming by sustaining H3K9me3 and CpG methylation at pluripotency gene promoters
Recent studies have boosted our understanding of long noncoding RNAs (lncRNAs) in
numerous biological processes, but few have examined their roles in somatic cell …
numerous biological processes, but few have examined their roles in somatic cell …
Bromodomain 4: a cellular Swiss army knife
Abstract Bromodomain protein 4 (BRD4) is a transcriptional and epigenetic regulator that
plays a pivotal role in cancer and inflammatory diseases. BRD4 binds and stays associated …
plays a pivotal role in cancer and inflammatory diseases. BRD4 binds and stays associated …
[HTML][HTML] BRD4: New hope in the battle against glioblastoma
W Duan, M Yu, J Chen - Pharmacological research, 2023 - Elsevier
The BET family proteins, comprising BRD2, BRD3 and BRD4, represent epigenetic readers
of acetylated histone marks that play pleiotropic roles in the tumorigenesis and growth of …
of acetylated histone marks that play pleiotropic roles in the tumorigenesis and growth of …
C/EBPα creates elite cells for iPSC reprogramming by upregulating Klf4 and increasing the levels of Lsd1 and Brd4
Reprogramming somatic cells into induced pluripotent stem cells (iPSCs) is typically
inefficient and has been explained by elite-cell and stochastic models. We recently reported …
inefficient and has been explained by elite-cell and stochastic models. We recently reported …