A major challenge in the post-genome era will be determination of the functions of the
encoded protein sequences. Since it is generally assumed that the function of a protein is …

Regulation, recognition and cell signaling involve the coordinated actions of many players.
To achieve this coordination, each participant must have a valid identification (ID) that is …

The large ribosomal subunit catalyzes peptide bond formation and binds initiation,
termination, and elongation factors. We have determined the crystal structure of the large …

Atomic resolution structures are now available for more than 20 complexes of proteins with
specific RNAs. This review examines two main themes that appear in this set of structures. A …

The chemical shift of a nucleus, i, in a molecule arises from the nuclear shielding effect of an
applied magnetic field, caused by an induced magnetic field resulting from circulation of …

Recently developed solution NMR methods for measuring 2H, 13C, and 15N spin
relaxation, coupled with biosynthetic isotopic enrichment, permit the characterization of …

We report the crystal structure of a 58 nucleotide fragment of 23S ribosomal RNA bound to
ribosomal protein L11. This highly conserved ribonucleoprotein domain is the target for the …

A plethora of post-transcriptional mechanisms are involved in essential steps in the pathway
of genetic information expression in eukaryotes. These processes are specified by cis-acting …

Crystal structure of the unique RNA-binding domain of the influenza virus NS1 protein. - Abstract
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This review focuses on a very important but little understood type of molecular recognition—
the recognition between highly flexible molecular structures. The formation of a specific …