Recent advances in contrast-enhanced photoacoustic imaging: overcoming the physical and practical challenges

W Choi, B Park, S Choi, D Oh, J Kim, C Kim - Chemical Reviews, 2023 - ACS Publications
For decades now, photoacoustic imaging (PAI) has been investigated to realize its potential
as a niche biomedical imaging modality. Despite its highly desirable optical contrast and …

Micro/nanosystems for controllable drug delivery to the brain

M Tian, Z Ma, GZ Yang - The Innovation, 2024 - cell.com
Drug delivery to the brain is crucial in the treatment for central nervous system disorders.
While significant progress has been made in recent years, there are still major challenges in …

Magnetically steerable bacterial microrobots moving in 3D biological matrices for stimuli-responsive cargo delivery

MB Akolpoglu, Y Alapan, NO Dogan, SF Baltaci… - Science …, 2022 - science.org
Bacterial biohybrids, composed of self-propelling bacteria carrying micro/nanoscale
materials, can deliver their payload to specific regions under magnetic control, enabling …

Tracking and navigation of a microswarm under laser speckle contrast imaging for targeted delivery

Q Wang, Q Wang, Z Ning, KF Chan, J Jiang, Y Wang… - Science Robotics, 2024 - science.org
Micro/nanorobotic swarms consisting of numerous tiny building blocks show great potential
in biomedical applications because of their collective active delivery ability, enhanced …

Ultrasound trap** and navigation of microrobots in the mouse brain vasculature

A Del Campo Fonseca, C Glück, J Droux… - Nature …, 2023 - nature.com
The intricate and delicate anatomy of the brain poses significant challenges for the treatment
of cerebrovascular and neurodegenerative diseases. Thus, precise local drug delivery in …

Autonomous metal-organic framework nanorobots for active mitochondria-targeted cancer therapy

X Peng, S Tang, D Tang, D Zhou, Y Li, Q Chen… - Science …, 2023 - science.org
Nanorobotic manipulation to access subcellular organelles remains unmet due to the
challenge in achieving intracellular controlled propulsion. Intracellular organelles, such as …

Janus microparticles-based targeted and spatially-controlled piezoelectric neural stimulation via low-intensity focused ultrasound

M Han, E Yildiz, U Bozuyuk, A Aydin, Y Yu… - Nature …, 2024 - nature.com
Electrical stimulation is a fundamental tool in studying neural circuits, treating neurological
diseases, and advancing regenerative medicine. Injectable, free-standing piezoelectric …

Biohybrid microrobots locally and actively deliver drug-loaded nanoparticles to inhibit the progression of lung metastasis

F Zhang, Z Guo, Z Li, H Luan, Y Yu, AT Zhu, S Ding… - Science …, 2024 - science.org
Lung metastasis poses a formidable challenge in the realm of cancer treatment, with
conventional chemotherapy often falling short due to limited targeting and low accumulation …

Multifunctional 3D‐printed pollen grain‐inspired hydrogel microrobots for on‐demand anchoring and cargo delivery

YW Lee, JK Kim, U Bozuyuk, NO Dogan… - Advanced …, 2023 - Wiley Online Library
While a majority of wireless microrobots have shown multi‐responsiveness to implement
complex biomedical functions, their functional executions are strongly dependent on the …

tPA-anchored nanorobots for in vivo arterial recanalization at submillimeter-scale segments

B Wang, Q Wang, KF Chan, Z Ning, Q Wang, F Ji… - Science …, 2024 - science.org
Micro/nanorobots provide a promising approach for intravascular therapy with high
precision. However, blood vessel is a highly complex system, and performing interventional …