Background Multiple genome alignment remains a challenging problem. Effects of
recombination including rearrangement, segmental duplication, gain, and loss can create a …

The ciliate Tetrahymena thermophila is a model organism for molecular and cellular biology.
Like other ciliates, this species has separate germline and soma functions that are …

Species of malaria parasite that infect rodents have long been used as models for malaria
disease research. Here we report the whole-genome shotgun sequence of one species …

Noncoding DNA in the human–mouse orthologous intergenic regions contains 'islands' of
conserved sequences, the functions of which remain largely unknown. We hypothesized that …

The field of comparative genomics of malaria parasites has recently come of age with the
completion of the whole genome sequences of the human malaria parasite Plasmodium …

Single-stranded mRNA molecules form secondary structures through complementary self-
interactions. Several hypotheses have been proposed on the relationship between the …

The μ-opioid receptor (OPRM1) is the principal receptor target for both endogenous and
exogenous opioid analgesics. There are substantial individual differences in human …

Thousands of long noncoding RNAs (lncRNAs) have been discovered, yet the function of
the vast majority remains unclear. Here, we show that a p53-regulated lncRNA which we …

Despite the key role of the human ribosome in protein biosynthesis, little is known about the
extent of sequence variation in ribosomal DNA (rDNA) or its pre-rRNA and rRNA products …

Burkholderia mallei (Bm), the causative agent of the predominately equine disease
glanders, is a genetically uniform species that is very closely related to the much more …