Computational models of atrial fibrillation: Achievements, challenges, and perspectives for improving clinical care
Despite significant advances in its detection, understanding and management, atrial
fibrillation (AF) remains a highly prevalent cardiac arrhythmia with a major impact on …
fibrillation (AF) remains a highly prevalent cardiac arrhythmia with a major impact on …
Mathematical approaches to understanding and imaging atrial fibrillation: significance for mechanisms and management
NA Trayanova - Circulation research, 2014 - Am Heart Assoc
Atrial fibrillation (AF) is the most common sustained arrhythmia in humans. The mechanisms
that govern AF initiation and persistence are highly complex, of dynamic nature, and involve …
that govern AF initiation and persistence are highly complex, of dynamic nature, and involve …
Inter-subject variability in human atrial action potential in sinus rhythm versus chronic atrial fibrillation
Aims Human atrial electrophysiology exhibits high inter-subject variability in both sinus
rhythm (SR) and chronic atrial fibrillation (cAF) patients. Variability is however rarely …
rhythm (SR) and chronic atrial fibrillation (cAF) patients. Variability is however rarely …
Computational assessment of drug‐induced effects on the electrocardiogram: from ion channel to body surface potentials
Background and Purpose Understanding drug effects on the heart is key to safety
pharmacology assessment and anti‐arrhythmic therapy development. Here our goal is to …
pharmacology assessment and anti‐arrhythmic therapy development. Here our goal is to …
[HTML][HTML] Bridging experiments, models and simulations: an integrative approach to validation in computational cardiac electrophysiology
A Carusi, K Burrage… - American Journal of …, 2012 - journals.physiology.org
Computational models in physiology often integrate functional and structural information
from a large range of spatiotemporal scales from the ionic to the whole organ level. Their …
from a large range of spatiotemporal scales from the ionic to the whole organ level. Their …
A three-dimensional human atrial model with fiber orientation. Electrograms and arrhythmic activation patterns relationship
The most common sustained cardiac arrhythmias in humans are atrial tachyarrhythmias,
mainly atrial fibrillation. Areas of complex fractionated atrial electrograms and high dominant …
mainly atrial fibrillation. Areas of complex fractionated atrial electrograms and high dominant …
Unlocking data sets by calibrating populations of models to data density: A study in atrial electrophysiology
The understanding of complex physical or biological systems nearly always requires a
characterization of the variability that underpins these processes. In addition, the data used …
characterization of the variability that underpins these processes. In addition, the data used …
Metabolic considerations in atrial fibrillation―mechanistic insights and therapeutic opportunities―
M Harada, J Melka, Y Sobue, S Nattel - Circulation Journal, 2017 - jstage.jst.go.jp
Atrial fibrillation (AF) is the most common sustained arrhythmia in clinical practice and is
associated with morbidity and mortality. Over the past 2 decades, there have been major …
associated with morbidity and mortality. Over the past 2 decades, there have been major …
Computational modeling of electrophysiology and pharmacotherapy of atrial fibrillation: recent advances and future challenges
M Vagos, IGM van Herck, J Sundnes… - Frontiers in …, 2018 - frontiersin.org
The pathophysiology of atrial fibrillation (AF) is broad, with components related to the unique
and diverse cellular electrophysiology of atrial myocytes, structural complexity, and …
and diverse cellular electrophysiology of atrial myocytes, structural complexity, and …
Na/K pump regulation of cardiac repolarization: insights from a systems biology approach
The sodium-potassium pump is widely recognized as the principal mechanism for active ion
transport across the cellular membrane of cardiac tissue, being responsible for the creation …
transport across the cellular membrane of cardiac tissue, being responsible for the creation …