Animal and translational models of SARS-CoV-2 infection and COVID-19

MD Johansen, A Irving, X Montagutelli, MD Tate… - Mucosal …, 2020 - nature.com
COVID-19 is causing a major once-in-a-century global pandemic. The scientific and clinical
community is in a race to define and develop effective preventions and treatments. The …

Cytokine storm in COVID-19:“when you come out of the storm, you won't be the same person who walked in”

V Castelli, A Cimini, C Ferri - Frontiers in immunology, 2020 - frontiersin.org
In December 2019, a novel coronavirus, COVID-19, was discovered to be the causal agent
of a severe respiratory infection named SARS-CoV-2, and it has since been recognized …

Complement activation contributes to severe acute respiratory syndrome coronavirus pathogenesis

LE Gralinski, TP Sheahan, TE Morrison, VD Menachery… - MBio, 2018 - Am Soc Microbiol
Acute respiratory distress syndrome (ARDS) is immune-driven pathologies that are
observed in severe cases of severe acute respiratory syndrome coronavirus (SARS-CoV) …

SARS-CoV-2 and COVID-19: A genetic, epidemiological, and evolutionary perspective

M Sironi, SE Hasnain, B Rosenthal, T Phan… - Infection, genetics and …, 2020 - Elsevier
In less than five months, COVID-19 has spread from a small focus in Wuhan, China, to more
than 5 million people in almost every country in the world, dominating the concern of most …

[HTML][HTML] Genetic gateways to COVID‐19 infection: implications for risk, severity, and outcomes

M Debnath, M Banerjee, M Berk - The FASEB Journal, 2020 - ncbi.nlm.nih.gov
The dynamics, such as transmission, spatial epidemiology, and clinical course of
Coronavirus Disease‐2019 (COVID‐19) have emerged as the most intriguing features and …

Innate immune signaling and proteolytic pathways in the resolution or exacerbation of SARS-CoV-2 in Covid-19: key therapeutic targets?

JM Sallenave, L Guillot - Frontiers in immunology, 2020 - frontiersin.org
COVID-19 is caused by the Severe Acute Respiratory Syndrome (SARS) coronavirus (Cov)-
2, an enveloped virus with a positive-polarity, single-stranded RNA genome. The initial …

The role of dysregulated immune responses in COVID-19 pathogenesis

S Tahaghoghi-Hajghorbani, P Zafari, E Masoumi… - Virus research, 2020 - Elsevier
Abstract The coronavirus disease-2019 (COVID-19) which caused by severe acute
respiratory syndrome-related coronavirus (SARS-CoV-2), is a pandemic threat to global …

Overview of the pathogenesis of COVID‑19

C Li, Q He, H Qian, J Liu - … and Therapeutic Medicine, 2021 - spandidos-publications.com
At present, the pathogenesis of the novel coronavirus disease 2019 (COVID‑19) has not
been fully elucidated. Clinical and experimental findings from studies investigating COVID …

Genomes of the mouse collaborative cross

A Srivastava, AP Morgan, ML Najarian, VK Sarsani… - Genetics, 2017 - academic.oup.com
Abstract The Collaborative Cross (CC) is a multiparent panel of recombinant inbred (RI)
mouse strains derived from eight founder laboratory strains. RI panels are popular because …

Designing a multi-epitope peptide based vaccine against SARS-CoV-2

A Singh, M Thakur, LK Sharma, K Chandra - Scientific reports, 2020 - nature.com
COVID-19 pandemic has resulted in 16,114,449 cases with 646,641 deaths from the 217
countries, or territories as on July 27th 2020. Due to multifaceted issues and challenges in …