Cells interact with their environment, communicate among themselves, track time and make
decisions through functions controlled by natural regulatory genetic circuits consisting of …

In industrial bioprocesses, microbial metabolism dictates the product yields, and therefore,
our capacity to control it has an enormous potential to help us move towards a bio-based …

Human-associated bacteria secrete modified peptides to control host physiology and
remodel the microbiota species composition. Here we scanned 2,229 Human Microbiome …

Cells can be programmed to monitor and react to their environment using genetic circuits.
Design automation software maps a desired circuit function to a DNA sequence, a process …

Powerful distributed computing can be achieved by communicating cells that individually
perform simple operations. Here, we report design software to divide a large genetic circuit …

Multicellular systems, from bacterial biofilms to human organs, form interfaces (or
boundaries) between different cell collectives to spatially organize versatile functions,. The …

In 1961, Jacob and Monod proposed the operon model of gene regulation. At the model's
core was the modular assembly of regulators, operators, and structural genes. To illustrate …

INTRODUCTION Modern computing is based on sequential logic, in which the state of a
circuit depends both on the present inputs as well as the input history (memory) …

Biology leverages a range of electrical phenomena to extract and store energy, control
molecular reactions and enable multicellular communication. Microbes, in particular, have …

To build therapeutic strains, Escherichia coli Nissle (EcN) have been engineered to express
antibiotics, toxin-degrading enzymes, immunoregulators, and anti-cancer chemotherapies …