Speech biomarkers in rapid eye movement sleep behavior disorder and Parkinson disease

J Rusz, J Hlavnička, M Novotný, T Tykalová… - Annals of …, 2021 - Wiley Online Library
Objective This multilanguage study used simple speech recording and high‐end pattern
analysis to provide sensitive and reliable noninvasive biomarkers of prodromal versus …

Automated speech analysis in early untreated Parkinson's disease: Relation to gender and dopaminergic transporter imaging

J Rusz, T Tykalová, M Novotný… - European journal of …, 2022 - Wiley Online Library
Background The mechanisms underlying speech abnormalities in Parkinson's disease (PD)
remain poorly understood, with most of the available evidence based on male patients. This …

Defining speech subtypes in de novo Parkinson disease: response to long-term levodopa therapy

J Rusz, T Tykalova, M Novotny, D Zogala, K Sonka… - Neurology, 2021 - AAN Enterprises
Background and Objectives Patterns of speech disorder in Parkinson disease (PD), which
are highly variable across individual patients, have not been systematically studied. Our aim …

Distinct patterns of speech disorder in early-onset and late-onset de-novo Parkinson's disease

J Rusz, T Tykalová, M Novotný, E Růžička… - npj Parkinson's …, 2021 - nature.com
Substantial variability and severity of dysarthric patterns across Parkinson's disease (PD)
patients may reflect distinct phenotypic differences. We aimed to compare patterns of speech …

Acoustic assessment in mandarin-speaking Parkinson's disease patients and disease progression monitoring and brain impairment within the speech subsystem

Y Diao, H **e, Y Wang, B Zhao, A Yang… - npj Parkinson's …, 2024 - nature.com
Approximately 90% of Parkinson's patients (PD) suffer from dysarthria. However, there is
currently a lack of research on acoustic measurements and speech impairment patterns …

Short-term effect of dopaminergic medication on speech in early-stage Parkinson's disease

T Tykalova, M Novotny, E Ruzicka, P Dusek… - npj Parkinson's …, 2022 - nature.com
The effect of dopaminergic medication on speech has rarely been examined in early-stage
Parkinson's disease (PD) and the respective literature is inconclusive and limited by …

Speech acoustic indices for differential diagnosis between Parkinson's disease, multiple system atrophy and progressive supranuclear palsy

K Daoudi, B Das, T Tykalova, J Klempir… - npj Parkinson's …, 2022 - nature.com
While speech disorder represents an early and prominent clinical feature of atypical
parkinsonian syndromes such as multiple system atrophy (MSA) and progressive …

Acoustic tracking of pitch, modal, and subharmonic vibrations of vocal folds in Parkinson's disease and parkinsonism

J Hlavnička, R Čmejla, J Klempíř, E Růžička… - IEEE Access, 2019 - ieeexplore.ieee.org
The prominent and early presence of dysphonia is considered a valuable marker for
differentiation of idiopathic Parkinson's disease and parkinsonian syndromes. Objective …

Distinctive speech signature in cerebellar and parkinsonian subtypes of multiple system atrophy

J Rusz, T Tykalová, G Salerno, S Bancone… - Journal of …, 2019 - Springer
Although motor speech disorders represent an early and prominent clinical feature of
multiple system atrophy (MSA), the potential usefulness of speech assessment as a …

Speech and gait abnormalities in motor subtypes of de‐novo Parkinson's disease

J Rusz, R Krupička, S Vítečková… - CNS neuroscience & …, 2023 - Wiley Online Library
Aim To investigate the presence and relationship of temporal speech and gait parameters in
patients with postural instability/gait disorder (PIGD) and tremor‐dominant (TD) motor …