Candidate biomarkers in psychiatric disorders: state of the field
The field of psychiatry is hampered by a lack of robust, reliable and valid biomarkers that can
aid in objectively diagnosing patients and providing individualized treatment …
aid in objectively diagnosing patients and providing individualized treatment …
The genetic basis of major depressive disorder
J Flint - Molecular psychiatry, 2023 - nature.com
The genetic dissection of major depressive disorder (MDD) ranks as one of the success
stories of psychiatric genetics, with genome-wide association studies (GWAS) identifying …
stories of psychiatric genetics, with genome-wide association studies (GWAS) identifying …
An integrated cell atlas of the lung in health and disease
Single-cell technologies have transformed our understanding of human tissues. Yet, studies
typically capture only a limited number of donors and disagree on cell type definitions …
typically capture only a limited number of donors and disagree on cell type definitions …
Bi-ancestral depression GWAS in the Million Veteran Program and meta-analysis in> 1.2 million individuals highlight new therapeutic directions
Major depressive disorder is the most common neuropsychiatric disorder, affecting 11% of
veterans. Here we report results of a large meta-analysis of depression using data from the …
veterans. Here we report results of a large meta-analysis of depression using data from the …
Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions
Major depression is a debilitating psychiatric illness that is typically associated with low
mood and anhedonia. Depression has a heritable component that has remained difficult to …
mood and anhedonia. Depression has a heritable component that has remained difficult to …
Altered connectivity in depression: GABA and glutamate neurotransmitter deficits and reversal by novel treatments
The mechanisms underlying the pathophysiology and treatment of depression and stress-
related disorders remain unclear, but studies in depressed patients and rodent models are …
related disorders remain unclear, but studies in depressed patients and rodent models are …
The genetic architecture of depression in individuals of East Asian ancestry: a genome-wide association study
O Giannakopoulou, K Lin, X Meng, N Cai, JA Revez, MJ Adams, TFM Andlauer, G Breen… - Nature …, 2020 - nature.com
Minimal phenoty** refers to the reliance on the use of a small number of self-reported
items for disease case identification, increasingly used in genome-wide association studies …
items for disease case identification, increasingly used in genome-wide association studies …
Phenotype integration improves power and preserves specificity in biobank-based genetic studies of major depressive disorder
Biobanks often contain several phenotypes relevant to diseases such as major depressive
disorder (MDD), with partly distinct genetic architectures. Researchers face complex …
disorder (MDD), with partly distinct genetic architectures. Researchers face complex …