The health sector is one of the keys to sustainable development. Although it is directly
related to only one Sustainable Development Goal (Goal 3,“Ensuring a healthy life and …

Tissue Engineering (TE) is a branch of Regenerative Medicine (RM) that combines stem
cells and biomaterial scaffolds to create living tissue constructs to restore patients' organs …

ABSTRACT Background: The experience of Kymriah® and Yescarta® provides real-world
examples of how health-care systems approach and manage the reimbursement of one-off …

Innovative reimbursement mechanisms have long been considered potential solutions to the
data uncertainty associated with one-off, high-value gene therapies that have long-term …

This last decade has been marked by significant advances in the development of cell and
gene (C&G) therapies, such as gene targeting or stem cell-based therapies. C&G therapies …

Analyses of inequalities related to prevention and cancer therapeutics/care show disparities
between countries with different economic standing, and within countries with high Gross …

Background Advanced therapy medicinal products (ATMPs) represent an important
cornerstone for innovation in healthcare. However, uncertainty on the value, the high …

Gene therapies offer potentially life-changing benefits for patients, but their unprecedented
high prices exacerbate challenges for reimbursement. Payers must confront high budgetary …

The concept of a reference case, first proposed by the US Panel on Cost-Effectiveness in
Health and Medicine, has been used to specify the required methodological features of …

Background The aims of this research were to provide a better understanding of the specific
evidence needs for assessment of clinical and cost-effectiveness of cell and gene therapies …