The composition of microbiota and the gut-brain axis is increasingly considered a factor in
the development of various pathological conditions. The etiology of multiple sclerosis (MS) …

Multiple sclerosis (MS) is a complex disease of the CNS thought to require an environmental
trigger. Gut dysbiosis is common in MS, but specific causative species are unknown. To …

Pellino1 (Peli1) is a highly conserved E3 Ub ligase that exerts its biological functions by
mediating target protein ubiquitination. Extensive evidence has demonstrated the crucial …

Methylglyoxal (MGO) is a highly reactive metabolite generated by glycolysis. Although
abnormal accumulation of MGO has been reported in several autoimmune diseases such as …

Background Immune cell metabolism governs the outcome of immune responses and
contributes to the development of autoimmunity by controlling lymphocyte pathogenic …

While immunotherapy has revolutionized cancer treatment, its safety has been hampered by
immunotherapy-related adverse events. Unexpectedly, we show that Mediator complex …

Multiple sclerosis (MS) is a neurodegenerative disease marked by chronic
neuroinflammation thought to be mediated by the inflammasome pathway. Connexin 43 …

Multiple sclerosis (MS) is a chronic central nervous system (CNS) disorder characterized by
demyelination, neuronal damage, and oligodendrocyte depletion. Reliable biomarkers are …

It is known that certain human leukocyte antigen (HLA) genes are associated with
autoimmune central nervous system (CNS) diseases, such as multiple sclerosis (MS), but …

Experimental autoimmune encephalomyelitis (EAE) is an animal model of central nervous
system (CNS) autoimmunity. It is most commonly used to mimic aspects of multiple sclerosis …