Assembloid models of cell-cell interaction to study tissue and disease biology
Neurodevelopment involves the migration, projection, and integration of various cell types
across different regions of the nervous system. Assembloids are self-organizing systems …
across different regions of the nervous system. Assembloids are self-organizing systems …
Human assembloids reveal the consequences of CACNA1G gene variants in the thalamocortical pathway
Abnormalities in thalamocortical crosstalk can lead to neuropsychiatric disorders. Variants in
CACNA1G, which encodes the α1G subunit of the thalamus-enriched T-type calcium …
CACNA1G, which encodes the α1G subunit of the thalamus-enriched T-type calcium …
[HTML][HTML] Organoids as a model of status epilepticus
Status epilepticus (SE) is a neurological emergency that can be studied in animal models,
particularly mice. However, these models are labour-intensive and require large numbers of …
particularly mice. However, these models are labour-intensive and require large numbers of …
[HTML][HTML] Protocol for generating human assembloids to investigate thalamocortical and corticothalamic synaptic transmission and plasticity
Human induced pluripotent stem cells (hiPSCs) can be used to generate assembloids that
recreate thalamocortical circuitry displaying short-term and long-term synaptic plasticity …
recreate thalamocortical circuitry displaying short-term and long-term synaptic plasticity …
Multi-Region Brain Organoid–Fusion Organoid with Cerebral, Endothelial and Mid-Hindbrain Components
A Kshirsagar, H Mnatsakanyan, S Kulkarni, J Guo… - bioRxiv, 2025 - biorxiv.org
Brain organoid technology has revolutionized our ability to model human neurodevelopment
in vitro. However, current techniques remains limited by their reliance on simplified …
in vitro. However, current techniques remains limited by their reliance on simplified …