Progress in the field of precision medicine has changed the landscape of cancer therapy.
Precision medicine is propelled by technologies that enable molecular profiling, genomic …

Aurora kinase B (AURKB) is a mitotic serine/threonine protein kinase that belongs to the
aurora kinase family along with aurora kinase A (AURKA) and aurora kinase C (AURKC) …

Loss-of-function mutations in the retinoblastoma gene RB1 are common in several treatment-
refractory cancers such as small-cell lung cancer and triple-negative breast cancer. To …

Mitotic errors can activate cyclic GMP–AMP synthase (cGAS) and induce type I interferon
(IFN) signaling. Current models propose that chromosome segregation errors generate …

Centrosomes are membrane-less organelles that orchestrate a wide array of biological
functions by acting as microtubule organizing centers. Here, we report that caspase-2 …

Glioblastoma (GBM) is the most common primary adult brain tumor. Despite extensive
efforts, the median survival for GBM patients is approximately 14 months. GBM therapy could …

Selective orthosteric inhibition of kinases has been challenging due to the conserved active
site architecture of kinases and emergence of resistance mutants. Simultaneous inhibition of …

Aurora kinases control multiple events during cell cycle progression and are essential for
mitotic and meiotic bipolar spindle assembly and function. There are three Aurora kinases in …

In the eukaryotic cell cycle, a threshold level of cyclin B accumulation triggers the G2-to-M
transition, and subsequent cyclin B destruction triggers mitotic exit. The anaphase-promoting …

Although aromatic rings are common elements in pharmaceutically active compounds, the
presence of these motifs brings several liabilities with respect to the developability of a drug …