Highlights•The first step in metastasis is invasion of tumor cells into the stroma.•Stromal
collagen is dramatically remodeled during tumor progression.•Tumor cells can invade the …

During metastasis, cancer cells disseminate to other parts of the body by entering the
bloodstream in a process that is called intravasation. They then extravasate at metastatic …

Chemotaxis of tumour cells and stromal cells in the surrounding microenvironment is an
essential component of tumour dissemination during progression and metastasis. This …

Fibrillar collagen is the most abundant extracellular matrix (ECM) constituent which
maintains the structure of most interstitial tissues and organs, including skin, gut, and breast …

Proinflammatory cytokines are frequently observed in the tumor microenvironment, and
chronic inflammation is involved in cancer initiation and progression. We show that cytokine …

In about half of all human cancers, the tumor suppressor p53 protein is either lost or
mutated, frequently resulting in the expression of a transcriptionally inactive mutant p53 …

Cancer cell migration and invasion underlie metastatic dissemination, one of the major
problems in cancer. Tumour cells exhibit a striking variety of invasion strategies. Importantly …

In crowded microenvironments, migrating cells must find or make a path. Amoeboid cells are
thought to find a path by deforming their bodies to squeeze through tight spaces. Yet, some …

To initiate adaptive immunity, dendritic cells (DCs) move from parenchymal tissues to
lymphoid organs by migrating along stromal scaffolds that display the glycoprotein …

Contact guidance is a powerful topographical cue that induces persistent directional cell
migration. Healthy tissue stroma is characterized by a meshwork of wavy extracellular matrix …