Cholinergic system changes in Parkinson's disease: emerging therapeutic approaches
In patients with Parkinson's disease, heterogeneous cholinergic system changes can occur
in different brain regions. These changes correlate with a range of clinical features, both …
in different brain regions. These changes correlate with a range of clinical features, both …
Muscarinic acetylcholine receptors for psychotic disorders: bench-side to clinic
Modern interest in muscarinic acetylcholine receptor (mAChR) activators for schizophrenia
began in the 1990s when xanomeline, an M 1/M 4-preferring mAChR agonist developed for …
began in the 1990s when xanomeline, an M 1/M 4-preferring mAChR agonist developed for …
Neurobiological mechanisms of nicotine reward and aversion
Neuronal nicotinic acetylcholine receptors (nAChRs) regulate the rewarding actions of
nicotine contained in tobacco that establish and maintain the smoking habit. nAChRs also …
nicotine contained in tobacco that establish and maintain the smoking habit. nAChRs also …
[HTML][HTML] Acetylcholine bidirectionally regulates learning and memory
Q Huang, C Liao, F Ge, J Ao, T Liu - Journal of Neurorestoratology, 2022 - Elsevier
Acetylcholine (ACh) is one of the most important neurotransmitters in the central cholinergic
system; it specifically binds to muscarinic and nicotinic receptors and is degraded by …
system; it specifically binds to muscarinic and nicotinic receptors and is degraded by …
Polysynaptic inhibition between striatal cholinergic interneurons shapes their network activity patterns in a dopamine-dependent manner
Striatal activity is dynamically modulated by acetylcholine and dopamine, both of which are
essential for basal ganglia function. Synchronized pauses in the activity of striatal …
essential for basal ganglia function. Synchronized pauses in the activity of striatal …
The human VGLUT3-pT8I mutation elicits uneven striatal DA signaling, food or drug maladaptive consumption in male mice
Cholinergic striatal interneurons (ChIs) express the vesicular glutamate transporter 3
(VGLUT3) which allows them to regulate the striatal network with glutamate and …
(VGLUT3) which allows them to regulate the striatal network with glutamate and …
Striatal cholinergic transmission. Focus on nicotinic receptors' influence in striatal circuits
M Assous - European Journal of Neuroscience, 2021 - Wiley Online Library
The critical role of acetylcholine (ACh) in the basal ganglia is evident from the effect of
cholinergic agents in patients suffering from several related neurological disorders, such as …
cholinergic agents in patients suffering from several related neurological disorders, such as …
Axo-glial interactions between midbrain dopamine neurons and oligodendrocyte lineage cells in the anterior corpus callosum
M Caldwell, V Ayo-Jibunoh, JC Mendoza… - Brain Structure and …, 2023 - Springer
Oligodendrocyte progenitor cells (OPCs) receive synaptic innervation from glutamatergic
and GABAergic axons and can be dynamically regulated by neural activity, resulting in …
and GABAergic axons and can be dynamically regulated by neural activity, resulting in …
Cholinergic dysfunction in the dorsal striatum promotes habit formation and maladaptive eating
M Favier, H Janickova, D Justo… - The Journal of …, 2020 - Am Soc Clin Investig
Dysregulation of habit formation has been recently proposed as pivotal to eating disorders.
Here, we report that a subset of patients suffering from restrictive anorexia nervosa have …
Here, we report that a subset of patients suffering from restrictive anorexia nervosa have …
The mesencephalic locomotor region: multiple cell types, multiple behavioral roles, and multiple implications for disease
D Ryczko - The Neuroscientist, 2024 - journals.sagepub.com
The mesencephalic locomotor region (MLR) controls locomotion in vertebrates. In humans
with Parkinson disease, locomotor deficits are increasingly associated with decreased …
with Parkinson disease, locomotor deficits are increasingly associated with decreased …