Cancer cell identity and plasticity are required in transition states, such as epithelial–
mesenchymal transition (EMT) and mesenchymal–epithelial transition (MET), in primary …

Metastasis is the primary cause of cancer morbidity and mortality. The process involves a
complex interplay between intrinsic tumor cell properties as well as interactions between …

Triple-negative breast cancer (TNBC) is an aggressive subtype associated with early
metastatic recurrence and worse patient outcomes. TNBC tumors express molecular …

In the last decades, the role of the microenvironment in tumor progression and therapeutic
outcome has gained increasing attention. Cancer-associated fibroblasts (CAFs) have …

Experimental evidence accumulated over decades has implicated epithelial–mesenchymal
plasticity (EMP), which collectively encompasses epithelial–mesenchymal transition and the …

Epithelial‐to‐mesenchymal transition (EMT) and its reverse mesenchymal‐to‐epithelial
transition (MET) have been suggested to play crucial roles in metastatic dissemination of …

Cancer metastasis and therapy resistance are the major unsolved clinical challenges, and
account for nearly all cancer-related deaths. Both metastasis and therapy resistance are …

Epithelial/mesenchymal transition (EMT) has emerged as a key regulator of metastasis by
facilitating tumor cell invasion and dissemination to distant organs. Recent evidences …

Metastasis is the leading cause of mortality among cancer patients. Dissemination enabled
by an epithelial-to-mesenchymal transition (EMT) of carcinoma cells has long been …

Genetic and phenotypic heterogeneity contribute to the generation of diverse tumor cell
populations, thus enhancing cancer aggressiveness and therapy resistance. Compared to …