1, 2, 3, 4-Tetrahydro-β-carbolines (THβCs) are a pharmacologically important group of
compounds belonging to the indole alkaloids. C1-Substituted optically active THβCs have …

Introduction: A century after its discovery, American trypanosomiasis or Chagas disease
remains a serious health problem in Latin America, where it affects around 7–8 million …

The ever-increasing demand for natural products and biotechnology derived from bees and
ultra-modernization of various analytical devices has facilitated the rational and planned …

A series of novel hybrids β-carboline-4-thiazolidinones were synthesized and evaluated for
their in vitro antitumor activity against human cancer cell lines and for antiviral activity …

There is an urgent need for new inhibitors against T. cruzi, a protozoal infection that affects
about 8 million people annually around the world. In this study, we describe the synthesis …

The present work aimed to investigate the curative effect of benznidazole (BZL) in
combination with other patented drugs [nifurtimox (NFX), posaconazole (POS) or …

Background Chagas' disease is a condition caused by the protozoan Trypanosoma cruzi
that affects millions of people, mainly in Latin America where it is considered endemic. The …

Chagasic cardiomyopathy caused by Trypanosoma cruzi is a major health concern in Latin
America and among immigrant populations in non-endemic areas. T. cruzi has a high affinity …

Chagas Disease is a neglected tropical disease caused by the protozoan parasite
Trypanosoma cruzi, affecting 6–8 million people, mainly in Latin America. The medical …

Metal compounds seem to be a promising approach in the search of new therapeutic
solutions for neglected tropical diseases. In this chapter, efforts in the design of prospective …