Acute ischemic stroke (AIS) afflicts millions of individuals worldwide. Despite the
advancements in thrombolysis and thrombectomy facilitating proximal large artery …

Ischemic stroke is associated with increasing morbidity and has become the main cause of
death and disability worldwide. Cerebral edema is a serious complication arising from …

Background Trauma and a subsequent hemorrhagic shock (T/HS) result in insufficient
oxygen delivery to tissues and multiple organ failure. Extracellular adenosine, which is a …

Aims Mitochondrial dysfunction is a critical pathological change in cerebral ischemia.
Mitochondrial pyruvate carrier 1 (MPC1) is a mitochondrial inner membrane protein carrier …

Brain injury develops from a complex series of pathophysiological phases, resulting in acute
necrotic or delayed apoptotic cell death after traumatic brain injury (TBI). Inhibition of …

Enhancer of zeste homolog 2 (EZH2), a core component of polycomb repressive component
2 is overexpressed in a variety of cancers and recognized as a therapeutic target molecule …

Stroke patients show some degree of spontaneous functional recovery, but this is not
sufficient to prevent long-term disability. One promising approach is to characterize the …

Social isolation is associated with poor stroke outcome, but the underlying molecular
mechanisms were largely unknown. In male Balb/C mice exposed to transient middle …

The phosphodiesterase (PDE) superfamily comprises enzymes responsible for the cAMP
and cGMP degradation to AMP and GMP. PDEs are abundant in the brain, where they are …

Background/Aim: Circadian rhythm proteins (CRP) play critical roles in both physiological
and pathophysiological conditions, including neurodegenerative disorders. As member of …