Biopolymer-based functional composites for medical applications
Over the last decade, numerous biopolymers have received more attention in medical
applications involving novel biomaterials because of their biocompatibility, biodegradability …
applications involving novel biomaterials because of their biocompatibility, biodegradability …
Pathomechanism of intervertebral disc degeneration
T Oichi, Y Taniguchi, Y Oshima, S Tanaka, T Saito - JOR spine, 2020 - Wiley Online Library
Intervertebral disc degeneration (IDD) is the main contributor to low back pain, which is a
leading cause of disability worldwide. Although substantial progress has been made in …
leading cause of disability worldwide. Although substantial progress has been made in …
3D Bioprinting of Multifunctional Dynamic Nanocomposite Bioinks Incorporating Cu‐Doped Mesoporous Bioactive Glass Nanoparticles for Bone Tissue Engineering
Bioprinting has seen significant progress in recent years for the fabrication of bionic tissues
with high complexity. However, it remains challenging to develop cell‐laden bioinks …
with high complexity. However, it remains challenging to develop cell‐laden bioinks …
Mechanical Signal‐Tailored Hydrogel Microspheres Recruit and Train Stem Cells for Precise Differentiation
The aberrant mechanical microenvironment in degenerated tissues induces misdirection of
cell fate, making it challenging to achieve efficient endogenous regeneration. Herein, a …
cell fate, making it challenging to achieve efficient endogenous regeneration. Herein, a …
Development of a nanohybrid peptide hydrogel for enhanced intervertebral disc repair and regeneration
Effective therapeutic approaches to overcome the heterogeneous pro-inflammatory and
inhibitory extracellular matrix (ECM) microenvironment are urgently needed to achieve …
inhibitory extracellular matrix (ECM) microenvironment are urgently needed to achieve …
IVD progenitor cells: a new horizon for understanding disc homeostasis and repair
FJ Lyu, KM Cheung, Z Zheng, H Wang… - Nature Reviews …, 2019 - nature.com
Intervertebral disc (IVD) degeneration is associated with low back pain. In IVDs, a high
mechanical load, high osmotic pressure and hypoxic conditions create a hostile …
mechanical load, high osmotic pressure and hypoxic conditions create a hostile …
[HTML][HTML] Mechanisms of endogenous repair failure during intervertebral disc degeneration
Intervertebral disc (IVD) degeneration is frequently associated with Low back pain (LBP),
which can severely reduce the quality of human life and cause enormous economic loss …
which can severely reduce the quality of human life and cause enormous economic loss …
Dual delivery of stem cells and insulin-like growth factor-1 in coacervate-embedded composite hydrogels for enhanced cartilage regeneration in osteochondral …
Exogenous dual delivery of progenitor cell population and therapeutic growth factors (GFs)
is one of alternative tissue engineering strategies for osteochondral tissue regeneration. In …
is one of alternative tissue engineering strategies for osteochondral tissue regeneration. In …
[HTML][HTML] Biofunctionalized aligned microgels provide 3D cell guidance to mimic complex tissue matrices
JC Rose, DB Gehlen, T Haraszti, J Köhler, CJ Licht… - Biomaterials, 2018 - Elsevier
Natural healing is based on highly orchestrated processes, in which the extracellular matrix
plays a key role. To resemble the native cell environment, we introduce an artificial …
plays a key role. To resemble the native cell environment, we introduce an artificial …
The nucleus pulposus microenvironment in the intervertebral disc: the fountain of youth?
The intervertebral disc (IVD) is a complex tissue, and its degeneration remains a problem for
patients, without significant improvement in treatment strategies. This mostly age-related …
patients, without significant improvement in treatment strategies. This mostly age-related …