Three dimensional bioprinting is an emerging fabrication technique in the field of tissue
engineering. Extrusion-based bioprinting is one of the widely employed biofabrication …

Increased cardiovascular disease in aging is partly a consequence of the vascular
endothelial cell (EC) senescence and associated vascular dysfunction. In this contest, EC …

DOT1 (disruptor of telomeric silencing; also called Kmt4) was initially discovered in budding
yeast in a genetic screen for genes whose deletion confers defects in telomeric silencing …

Biophysical signals act as potent regulators of stem cell function, lineage commitment, and
epigenetic status. In recent years, synthetic biomaterials have been used to study a wide …

In atherosclerosis, plaques preferentially develop in arterial regions of disturbed blood flow
(d-flow), which alters endothelial gene expression and function. Here, we determined that d …

Joint tissues are exquisitely sensitive to their mechanical environment, and mechanical
loading may be the most important external factor regulating the development and long‐term …

The nicotinamide adenine dinucleotide (NAD+)-dependent histone deacetylase Sir2
regulates life-span in various species. Mammalian homologs of Sir2 are called sirtuins …

The mitogen-activated protein kinases (MAPKs) are a family of serine/threonine kinases that
play an essential role in signal transduction by modulating gene transcription in the nucleus …

The phenotypic expression and function of stem cells are regulated by their integrated
response to variable microenvironmental cues, including growth factors and cytokines …

Advances in stem cell biology have afforded promising results for the generation of various
cell types for therapies against devastating diseases. However, a prerequisite for realizing …