Molecular mechanisms and potential therapeutical targets in Huntington's disease
C Zuccato, M Valenza, E Cattaneo - Physiological reviews, 2010 - journals.physiology.org
Huntington's disease (HD) is a neurodegenerative disorder caused by a CAG repeat
expansion in the gene encoding for huntingtin protein. A lot has been learned about this …
expansion in the gene encoding for huntingtin protein. A lot has been learned about this …
Metabolic dysfunction in Alzheimer's disease and related neurodegenerative disorders
Alzheimer's disease and other related neurodegenerative diseases are highly debilitating
disorders that affect millions of people worldwide. Efforts towards develo** effective …
disorders that affect millions of people worldwide. Efforts towards develo** effective …
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways
Through genome-wide association meta-analyses of up to 133,010 individuals of European
ancestry without diabetes, including individuals newly genotyped using the Metabochip, we …
ancestry without diabetes, including individuals newly genotyped using the Metabochip, we …
Beyond the brain: widespread pathology in Huntington's disease
Huntington's disease (HD) is an inherited neurodegenerative disorder caused by a
polyglutamine stretch in the huntingtin protein. Today, more than 15 years after the genetic …
polyglutamine stretch in the huntingtin protein. Today, more than 15 years after the genetic …
Insulin, IGF-1 and GLP-1 signaling in neurodegenerative disorders: targets for disease modification?
Abstract Insulin and Insulin Growth Factor-1 (IGF-1) play a major role in body homeostasis
and glucose regulation. They also have paracrine/autocrine functions in the brain. The …
and glucose regulation. They also have paracrine/autocrine functions in the brain. The …
Significance of brain glucose hypometabolism, altered insulin signal transduction, and insulin resistance in several neurological diseases
E Blázquez, V Hurtado-Carneiro… - Frontiers in …, 2022 - frontiersin.org
Several neurological diseases share pathological alterations, even though they differ in their
etiology. Neuroinflammation, altered brain glucose metabolism, oxidative stress …
etiology. Neuroinflammation, altered brain glucose metabolism, oxidative stress …
The molecular genetics of Huntington disease—a history
GP Bates - Nature Reviews Genetics, 2005 - nature.com
The Huntington disease gene was mapped to human chromosome 4p in 1983 and 10 years
later the pathogenic mutation was identified as a CAG-repeat expansion. Our current …
later the pathogenic mutation was identified as a CAG-repeat expansion. Our current …
The use of the R6 transgenic mouse models of Huntington's disease in attempts to develop novel therapeutic strategies
JY Li, N Popovic, P Brundin - NeuroRx, 2005 - Elsevier
Huntington's disease (HD) is a genetic neurodegenerative disorder. Since identification of
the disease-causing gene in 1993, a number of genetically modified animal models of HD …
the disease-causing gene in 1993, a number of genetically modified animal models of HD …
Nuclear localization of ataxin-3 is required for the manifestation of symptoms in SCA3: in vivo evidence
U Bichelmeier, T Schmidt, J Hübener, J Boy… - Journal of …, 2007 - Soc Neuroscience
Spinocerebellar ataxia type 3 (SCA3) is an autosomal dominantly inherited
neurodegenerative disorder caused by the expansion of a CAG repeat in the MJD1 gene …
neurodegenerative disorder caused by the expansion of a CAG repeat in the MJD1 gene …
Mutant huntingtin impairs immune cell migration in Huntington disease
In Huntington disease (HD), immune cells are activated before symptoms arise; however, it
is unclear how the expression of mutant huntingtin (htt) compromises the normal functions of …
is unclear how the expression of mutant huntingtin (htt) compromises the normal functions of …