Metal sensing by DNA
Metal ions are essential to many chemical, biological, and environmental processes. In the
past two decades, many DNA-based metal sensors have emerged. While the main …
past two decades, many DNA-based metal sensors have emerged. While the main …
Ribozymes, riboswitches and beyond: regulation of gene expression without proteins
Although various functions of RNA are carried out in conjunction with proteins, some
catalytic RNAs, or ribozymes, which contribute to a range of cellular processes, require little …
catalytic RNAs, or ribozymes, which contribute to a range of cellular processes, require little …
Highly efficient expression of circular RNA aptamers in cells using autocatalytic transcripts
RNA aptamers and RNA aptamer-based devices can be genetically encoded and
expressed in cells to probe and manipulate cellular function. However, their usefulness in …
expressed in cells to probe and manipulate cellular function. However, their usefulness in …
[HTML][HTML] Tertiary contacts distant from the active site prime a ribozyme for catalysis
M Martick, WG Scott - Cell, 2006 - cell.com
Minimal hammerhead ribozymes have been characterized extensively by static and time-
resolved crystallography as well as numerous biochemical analyses, leading to mutually …
resolved crystallography as well as numerous biochemical analyses, leading to mutually …
A widespread self-cleaving ribozyme class is revealed by bioinformatics
A Roth, Z Weinberg, AGY Chen, PB Kim… - Nature chemical …, 2014 - nature.com
Ribozymes are noncoding RNAs that promote chemical transformations with rate
enhancements approaching those of protein enzymes. Although ribozymes are likely to …
enhancements approaching those of protein enzymes. Although ribozymes are likely to …
An RNA-cleaving threose nucleic acid enzyme capable of single point mutation discrimination
Y Wang, Y Wang, D Song, X Sun, Z Li, JY Chen… - Nature Chemistry, 2022 - nature.com
Threose nucleic acid has been considered a potential evolutionary progenitor of RNA
because of its chemical simplicity, base pairing properties and capacity for higher-order …
because of its chemical simplicity, base pairing properties and capacity for higher-order …
Riboswitches: emerging themes in RNA structure and function
RK Montange, RT Batey - Annu. Rev. Biophys., 2008 - annualreviews.org
Riboswitches are RNAs capable of binding cellular metabolites using a diverse array of
secondary and tertiary structures to modulate gene expression. The recent determination of …
secondary and tertiary structures to modulate gene expression. The recent determination of …
The catalytic diversity of RNAs
The natural RNA enzymes catalyse phosphate-group transfer and peptide-bond formation.
Initially, metal ions were proposed to supply the chemical versatility that nucleotides lack. In …
Initially, metal ions were proposed to supply the chemical versatility that nucleotides lack. In …
Topology of three-way junctions in folded RNAs
A Lescoute, E Westhof - Rna, 2006 - rnajournal.cshlp.org
The three-way junctions contained in X-ray structures of folded RNAs have been compiled
and analyzed. Three-way junctions with two helices approximately coaxially stacked can be …
and analyzed. Three-way junctions with two helices approximately coaxially stacked can be …
Biologically inspired synthetic enzymes made from DNA
K Schlosser, Y Li - Chemistry & biology, 2009 - cell.com
In cells, DNA typically consists of two antiparallel strands arranged in a double-helical
structure, which is central to its fundamental role in storing and transmitting genetic …
structure, which is central to its fundamental role in storing and transmitting genetic …