Once and only once: mechanisms of centriole duplication and their deregulation in disease

EA Nigg, AJ Holland - Nature reviews Molecular cell biology, 2018 - nature.com
Centrioles are conserved microtubule-based organelles that form the core of the centrosome
and act as templates for the formation of cilia and flagella. Centrioles have important roles in …

Mechanism and regulation of centriole and cilium biogenesis

DK Breslow, AJ Holland - Annual review of biochemistry, 2019 - annualreviews.org
The centriole is an ancient microtubule-based organelle with a conserved nine-fold
symmetry. Centrioles form the core of centrosomes, which organize the interphase …

[HTML][HTML] Human iPSC-derived cerebral organoids model cellular features of lissencephaly and reveal prolonged mitosis of outer radial glia

M Bershteyn, TJ Nowakowski, AA Pollen, E Di Lullo… - Cell stem cell, 2017 - cell.com
Classical lissencephaly is a genetic neurological disorder associated with mental
retardation and intractable epilepsy, and Miller-Dieker syndrome (MDS) is the most severe …

FMRP modulates neural differentiation through m6A-dependent mRNA nuclear export

BM Edens, C Vissers, J Su, S Arumugam, Z Xu, H Shi… - Cell reports, 2019 - cell.com
Summary N 6-methyladenosine (m 6 A) modification of mRNA is emerging as a vital
mechanism regulating RNA function. Here, we show that fragile X mental retardation protein …

Spindle positioning and its impact on vertebrate tissue architecture and cell fate

T Lechler, M Mapelli - Nature Reviews Molecular Cell Biology, 2021 - nature.com
In multicellular systems, oriented cell divisions are essential for morphogenesis and
homeostasis as they determine the position of daughter cells within the tissue and also, in …

[HTML][HTML] Zika virus infects neural progenitors in the adult mouse brain and alters proliferation

H Li, L Saucedo-Cuevas, JA Regla-Nava, G Chai… - Cell stem cell, 2016 - cell.com
Zika virus (ZIKV)-related neuropathology is an important global health concern. Several
studies have shown that ZIKV can infect neural stem cells in the develo** brain, but …

Differences and similarities between human and chimpanzee neural progenitors during cerebral cortex development

F Mora-Bermúdez, F Badsha, S Kanton, JG Camp… - Elife, 2016 - elifesciences.org
Human neocortex expansion likely contributed to the remarkable cognitive abilities of
humans. This expansion is thought to primarily reflect differences in proliferation versus …

Making Ramón y Cajal proud: Development of cell identity and diversity in the cerebral cortex

DJ Di Bella, N Domínguez-Iturza, JR Brown, P Arlotta - Neuron, 2024 - cell.com
Since the beautiful images of Santiago Ramón y Cajal provided a first glimpse into the
immense diversity and complexity of cell types found in the cerebral cortex, neuroscience …

Cellular and molecular mechanisms linking human cortical development and evolution

B Libé-Philippot, P Vanderhaeghen - Annual review of genetics, 2021 - annualreviews.org
The cerebral cortex is at the core of brain functions that are thought to be particularly
developed in the human species. Human cortex specificities stem from divergent features of …

Map** the molecular and cellular complexity of cortical malformations

E Klingler, F Francis, D Jabaudon, S Cappello - Science, 2021 - science.org
INTRODUCTION The cerebral cortex, or neocortex, is critical to key mammalian skills such
as language, sociability, and sensorimotor control. This structure consists of dozens of …