The failure of animal models to predict therapeutic responses in humans is a major problem
that also brings into question their use for basic research. Organ-on-a-chip (organ chip) …

Organoids are in vitro miniaturized and simplified model systems of organs that have gained
enormous interest for modelling tissue development and disease, and for personalized …

Abstract Organs-on-chips (OoCs), also known as microphysiological systems or 'tissue
chips'(the terms are synonymous), have attracted substantial interest in recent years owing …

Predicting the effects of drugs before human clinical trials is at the heart of drug screening
and discovery processes. The cost of drug discovery is steadily increasing owing to the …

The pharmaceutical industry has been desperately searching for efficient drug discovery
methods. Organ-on-a-Chip, a cutting-edge technology that can emulate the physiological …

One of the problems that has slowed the development and approval of new anticancer
therapies is the lack of preclinical models that can be used to identify key molecular, cellular …

The derivation of induced pluripotent stem cells (iPSCs) over a decade ago sparked
widespread enthusiasm for the development of new models of human disease, enhanced …

Organoids serve as a novel tool for disease modeling in three-dimensional multicellular
contexts. Static organoids, however, lack the requisite biophysical microenvironment such …

For the past century, experimental data obtained from animal studies have been required by
reviewers of scientific articles and grant applications to validate the physiological relevance …

Organ chips can recapitulate organ-level (patho) physiology, yet pharmacokinetic and
pharmacodynamic analyses require multi-organ systems linked by vascular perfusion. Here …