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Advancing human gut microbiota research by considering gut transit time
Accumulating evidence indicates that gut transit time is a key factor in sha** the gut
microbiota composition and activity, which are linked to human health. Both population-wide …
microbiota composition and activity, which are linked to human health. Both population-wide …
The changing metabolic landscape of bile acids–keys to metabolism and immune regulation
Bile acids regulate nutrient absorption and mitochondrial function, they establish and
maintain gut microbial community composition and mediate inflammation, and they serve as …
maintain gut microbial community composition and mediate inflammation, and they serve as …
Small intestinal bacterial overgrowth—pathophysiology and its implications for definition and management
D Bushyhead, EMM Quigley - Gastroenterology, 2022 - Elsevier
The concept of small intestinal bacterial overgrowth (SIBO) arose in the context of
maldigestion and malabsorption among patients with obvious risk factors that permitted the …
maldigestion and malabsorption among patients with obvious risk factors that permitted the …
Non-SCFA microbial metabolites associated with fiber fermentation and host health
Dietary fiber is degraded by commensal gut microbes to yield host-beneficial short-chain
fatty acids (SCFAs), but personalized responses to fiber supplementation highlight a role for …
fatty acids (SCFAs), but personalized responses to fiber supplementation highlight a role for …
Direct and indirect mechanisms by which the gut microbiota influence host serotonin systems
Mounting evidence highlights the pivotal role of enteric microbes as a dynamic interface with
the host. Indeed, the gut microbiota, located in the lumen of the gastrointestinal (GI) tract …
the host. Indeed, the gut microbiota, located in the lumen of the gastrointestinal (GI) tract …
Gut microbiota response to in vitro transit time variation is mediated by microbial growth rates, nutrient use efficiency and adaptation to in vivo transit time
Background Transit time is an important modulator of the human gut microbiome. The
inability to modify transit time as the sole variable hampers mechanistic in vivo microbiome …
inability to modify transit time as the sole variable hampers mechanistic in vivo microbiome …
Longitudinal flux balance analyses of a patient with episodic colonic inflammation reveals microbiome metabolic dynamics
We report the first use of constraint-based microbial community modeling on a single
individual with episodic inflammation of the gastrointestinal tract, who has a well …
individual with episodic inflammation of the gastrointestinal tract, who has a well …
Lactic acid bacteria in relieving constipation: mechanism, clinical application, challenge, and opportunity
T Zhang, W Liu, H Lu, T Cheng, L Wang… - Critical Reviews in …, 2025 - Taylor & Francis
Constipation is a prevalent gastrointestinal symptom that can considerably affect a patients'
quality of life. Although several drugs have been used to treat constipation, they are …
quality of life. Although several drugs have been used to treat constipation, they are …
Colorectal cancer-associated microbiome patterns and signatures
The gut microbiome is dynamic and shaped by diet, age, geography, and environment. The
disruption of normal gut microbiota (dysbiosis) is closely related to colorectal cancer (CRC) …
disruption of normal gut microbiota (dysbiosis) is closely related to colorectal cancer (CRC) …
Comparison of biochemical, microbial and mucosal mRNA expression in bile acid diarrhoea and irritable bowel syndrome with diarrhoea
Objective There are altered mucosal functions in irritable bowel syndrome with diarrhoea
(IBS-D);~ 30% of patients with IBS-D have abnormal bile acid (BA) metabolism (ABAM) and …
(IBS-D);~ 30% of patients with IBS-D have abnormal bile acid (BA) metabolism (ABAM) and …